| Protein | Synonyms | Taxonomy |
|---|
| 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | EC 4.1.1.45; Picolinate carboxylase | Homo sapiens (human) |
| Cellular tumor antigen p53 | Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 | Homo sapiens (human) |
| Indoleamine 2,3-dioxygenase 1 | IDO-1; EC 1.13.11.52; Indoleamine-pyrrole 2,3-dioxygenase | Homo sapiens (human) |
| Eukaryotic translation initiation factor 2-alpha kinase 1 | EC 2.7.11.1; Heme-controlled repressor; HCR; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; hHRI; Hemin-sensitive initiation factor 2-alpha kinase | Homo sapiens (human) |
| Indoleamine 2,3-dioxygenase 2 | IDO-2; EC 1.13.11.-; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1 | Homo sapiens (human) |
| Interferon beta | IFN-beta; Fibroblast interferon | Homo sapiens (human) |
| Aryl hydrocarbon receptor | Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76 | Homo sapiens (human) |
| Kynureninase | EC 3.7.1.3; L-kynurenine hydrolase | Homo sapiens (human) |
| Toll-like receptor 4 | EC 3.2.2.6; hToll | Homo sapiens (human) |
| Tumor necrosis factor | Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a | Homo sapiens (human) |
| Cyclin-dependent kinase inhibitor 1 | CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21 | Homo sapiens (human) |
| Tryptophan 2,3-dioxygenase | TDO; EC 1.13.11.11; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase | Homo sapiens (human) |
| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; 2.6.1.39; Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; 2.6.1.7; | Homo sapiens (human) |
| eIF-2-alpha kinase GCN2 | EC 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein | Homo sapiens (human) |
| Interferon gamma | IFN-gamma; Immune interferon | Homo sapiens (human) |
| Kynurenine formamidase | KFA; KFase; EC 3.5.1.9; Arylformamidase; N-formylkynurenine formamidase; FKF | Homo sapiens (human) |
| Kynurenine 3-monooxygenase | EC 1.14.13.9; Kynurenine 3-hydroxylase | Homo sapiens (human) |
| 3-hydroxyanthranilate 3,4-dioxygenase | EC 1.13.11.6; 3-hydroxyanthranilate oxygenase; 3-HAO; h3HAO; 3-hydroxyanthranilic acid dioxygenase; HAD | Homo sapiens (human) |
| Interleukin-1 receptor type 2 | IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II | Homo sapiens (human) |
| Nitric oxide synthase | | Homo sapiens (human) |
| Compound | Description |
|---|
| melatonin | A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant. |
| sapropterin | RN given refers to parent cpd; co-factor required for catalytic activity of nitric oxide synthases |
| picolinic acid | iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206 |
| quinolinic acid | A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. |
| Dinoprostone | The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa. |
| anthranilic acid | RN given refers to parent cpd; structure in Negwer, 5th ed, #565 |
| glutaryl-coenzyme a | |
| kynurenic acid | A broad-spectrum excitatory amino acid antagonist used as a research tool. |
| crotonyl-coenzyme a | |
| xanthurenic acid | |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| 3-hydroxyanthranilic acid | An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. |
| 3-hydroxykynurenine | RN given refers to cpd without isomeric designation |
| N'-formylkynurenine | a photochemical breakdown product of tryptophan in proteins; RN given refers to parent cpd without isomeric designation |
| glutaconyl-coenzyme A | |
| cinnabarinic acid | structure |
| nicotinic acid adenine dinucleotide | intermediate in the biosynthesis of NAD |
| acetyl coenzyme a | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| kynurenine | A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway. |
| coenzyme a | |