Page last updated: 2024-10-06

Ion Channels and Their Functional Role in Vascular Endothelium

Proteins (16)

ProteinSynonymsTaxonomy
Short transient receptor potential channel 7TrpC7; Transient receptor protein 7; TRP-7; hTRP7Homo sapiens (human)
Short transient receptor potential channel 4TrpC4; Trp-related protein 4; hTrp-4; hTrp4Homo sapiens (human)
Potassium voltage-gated channel subfamily KQT member 3KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3Homo sapiens (human)
cGMP-dependent protein kinase 2cGK 2; cGK2; EC 2.7.11.12; cGMP-dependent protein kinase II; cGKIIHomo sapiens (human)
cGMP-dependent protein kinase 1 cGK 1; cGK1; EC 2.7.11.12; cGMP-dependent protein kinase I; cGKIHomo sapiens (human)
Adenylate cyclase type 10EC 4.6.1.1; AH-related protein; Adenylate cyclase homolog; Germ cell soluble adenylyl cyclase; hsAC; sAC; Testicular soluble adenylyl cyclaseHomo sapiens (human)
Short transient receptor potential channel 3TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3Homo sapiens (human)
Potassium voltage-gated channel subfamily KQT member 2KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2Homo sapiens (human)
Nitric oxide synthase, endothelialEC 1.14.13.39; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIIIHomo sapiens (human)
Guanylate cyclase soluble subunit alpha-2GCS-alpha-2; EC 4.6.1.2Homo sapiens (human)
Potassium voltage-gated channel subfamily KQT member 4KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4Homo sapiens (human)
Transient receptor potential cation channel subfamily V member 4TrpV4; Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OACHomo sapiens (human)
Potassium voltage-gated channel subfamily KQT member 5KQT-like 5; Potassium channel subunit alpha KvLQT5; Voltage-gated potassium channel subunit Kv7.5Homo sapiens (human)
Guanylate cyclase soluble subunit alpha-1GCS-alpha-1; EC 4.6.1.2; Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; Soluble guanylate cyclase large subunitHomo sapiens (human)
Guanylate cyclase soluble subunit beta-2GCS-beta-2; EC 4.6.1.2Homo sapiens (human)
Guanylate cyclase soluble subunit beta-1GCS-beta-1; EC 4.6.1.2; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunitHomo sapiens (human)

Compounds (5)

CompoundDescription
Nitric OxideA free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Cyclic AMPAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
pyrophosphate