Page last updated: 2024-10-06

Involvement of -secretase in neurodegenerative diseases

Proteins (16)

ProteinSynonymsTaxonomy
Amyloid-beta precursor proteinAPP; ABPP; APPI; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta A4 protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-IIHomo sapiens (human)
RAC-alpha serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alphaHomo sapiens (human)
RAC-beta serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-betaHomo sapiens (human)
SRSF protein kinase 2EC 2.7.11.1; SFRS protein kinase 2; Serine/arginine-rich protein-specific kinase 2; SR-protein-specific kinase 2Homo sapiens (human)
Amine oxidase [flavin-containing] BEC 1.4.3.4; Monoamine oxidase type B; MAO-BHomo sapiens (human)
Alpha-synucleinNon-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACPHomo sapiens (human)
BDNF/NT-3 growth factors receptorEC 2.7.10.1; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase BHomo sapiens (human)
RAC-gamma serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2Homo sapiens (human)
LegumainEC 3.4.22.34; Asparaginyl endopeptidase; Protease, cysteine 1Homo sapiens (human)
TAR DNA-binding protein 43TDP-43Homo sapiens (human)
Brain-derived neurotrophic factorBDNF; AbrineurinHomo sapiens (human)
Microtubule-associated protein tauNeurofibrillary tangle protein; Paired helical filament-tau; PHF-tauHomo sapiens (human)
Signal transducer and activator of transcription 1-alpha/betaTranscription factor ISGF-3 components p91/p84Homo sapiens (human)
Protein SETHLA-DR-associated protein II; Inhibitor of granzyme A-activated DNase; IGAAD; PHAPII; Phosphatase 2A inhibitor I2PP2A; I-2PP2A; Template-activating factor I; TAF-IHomo sapiens (human)
CCAAT/enhancer-binding protein betaC/EBP beta; Liver activator protein; LAP; Liver-enriched inhibitory protein; LIP; Nuclear factor NF-IL6; Transcription factor 5; TCF-5Homo sapiens (human)
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoformPP2A-beta; EC 3.1.3.16Homo sapiens (human)

Compounds (2)

CompoundDescription
DopamineOne of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
3,4-dihydroxyphenylacetaldehyde