Page last updated: 2024-10-06

Intrinsic Pathway for Apoptosis

Proteins (45)

ProteinSynonymsTaxonomy
14-3-3 protein etaProtein AS1Homo sapiens (human)
Phorbol-12-myristate-13-acetate-induced protein 1PMA-induced protein 1; Immediate-early-response protein APR; Protein NoxaHomo sapiens (human)
Dynein light chain 2, cytoplasmic8 kDa dynein light chain b; DLC8b; Dynein light chain LC8-type 2Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
E3 ubiquitin-protein ligase XIAPEC 2.3.2.27; Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; RING-type E3 ubiquitin transferase XIAP; X-linked inhibitor of apoptosis protein; X-linked IAPHomo sapiens (human)
Bcl-2-like protein 1Bcl2-L-1; Apoptosis regulator Bcl-XHomo sapiens (human)
Caspase-8CASP-8; EC 3.4.22.61; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACHHomo sapiens (human)
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformEC 3.1.3.16; CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoformHomo sapiens (human)
Calcineurin subunit B type 1Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1Homo sapiens (human)
Granzyme BEC 3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3EHomo sapiens (human)
Apoptosis regulator Bcl-2Homo sapiens (human)
Signal transducer and activator of transcription 3Acute-phase response factorHomo sapiens (human)
Caspase-3CASP-3; EC 3.4.22.56; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1Homo sapiens (human)
Mitogen-activated protein kinase 8MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1Homo sapiens (human)
Caspase-9CASP-9; EC 3.4.22.62; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6Homo sapiens (human)
BH3-interacting domain death agonistp22 BID; BIDHomo sapiens (human)
Apoptosis regulator BAX Bcl-2-like protein 4; Bcl2-L-4Homo sapiens (human)
Bcl2-associated agonist of cell death BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell deathHomo sapiens (human)
14-3-3 protein theta14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1Homo sapiens (human)
Bcl-2 homologous antagonist/killerApoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7Homo sapiens (human)
Bcl-2-binding component 3, isoforms 1/2JFY-1; p53 up-regulated modulator of apoptosisHomo sapiens (human)
14-3-3 protein sigmaEpithelial cell marker protein 1; StratifinHomo sapiens (human)
Cytochrome cHomo sapiens (human)
Gasdermin-DGasdermin domain-containing protein 1Homo sapiens (human)
Apoptotic protease-activating factor 1APAF-1Homo sapiens (human)
Bcl-2-like protein 11Bcl2-L-11; Bcl2-interacting mediator of cell deathHomo sapiens (human)
Glycylpeptide N-tetradecanoyltransferase 1EC 2.3.1.97; Myristoyl-CoA:protein N-myristoyltransferase 1; NMT 1; Type I N-myristoyltransferase; Peptide N-myristoyltransferase 1Homo sapiens (human)
Caspase-7CASP-7; EC 3.4.22.60; Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3Homo sapiens (human)
14-3-3 protein gammaProtein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
Transcription factor E2F1E2F-1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1Homo sapiens (human)
14-3-3 protein beta/alphaProtein 1054; Protein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
14-3-3 protein epsilon14-3-3EHomo sapiens (human)
14-3-3 protein zeta/deltaProtein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
Tumor suppressor ARFAlternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p14ARFHomo sapiens (human)
Complement component 1 Q subcomponent-binding protein, mitochondrialASF/SF2-associated protein p32; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; gC1q-R protein; p33; SF2AP32Homo sapiens (human)
Dynein light chain 1, cytoplasmic8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; Protein inhibitor of neuronal nitric oxide synthase; PINHomo sapiens (human)
Bcl-2-modifying factorHomo sapiens (human)
Gasdermin-EInversely correlated with estrogen receptor expression 1; ICERE-1; Non-syndromic hearing impairment protein 5Homo sapiens (human)
Methylthioribulose-1-phosphate dehydrataseMTRu-1-P dehydratase; EC 4.2.1.109; APAF1-interacting protein; hAPIPHomo sapiens (human)
Uveal autoantigen with coiled-coil domains and ankyrin repeatsHomo sapiens (human)
Cell death regulator AvenHomo sapiens (human)
Diablo homolog, mitochondrialDirect IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; SmacHomo sapiens (human)
Caspase recruitment domain-containing protein 8Apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; Tumor up-regulated CARD-containing antagonist of CASP9; TUCANHomo sapiens (human)

Compounds (4)

CompoundDescription
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.