Page last updated: 2024-10-06

Interconversion of nucleotide di- and triphosphates

Proteins (20)

ProteinSynonymsTaxonomy
Nucleoside diphosphate kinase, mitochondrialNDK; NDP kinase, mitochondrial; EC 2.7.4.6; Nucleoside diphosphate kinase D; NDPKD; nm23-H4Homo sapiens (human)
Glutaredoxin-1Thioltransferase-1; TTase-1Homo sapiens (human)
Thymidylate synthaseTS; TSase; EC 2.1.1.45Homo sapiens (human)
Adenylate kinase 4, mitochondrialAK 4; EC 2.7.4.10; EC 2.7.4.6; Adenylate kinase 3-like; GTP:AMP phosphotransferase AK4Homo sapiens (human)
Guanylate kinaseEC 2.7.4.8; GMP kinase; Guanylate kinase 1Homo sapiens (human)
Nucleoside diphosphate kinase ANDK A; NDP kinase A; EC 2.7.4.6; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated proteinHomo sapiens (human)
Nucleoside diphosphate kinase BNDK B; NDP kinase B; EC 2.7.4.6; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; 2.7.13.3; nm23-H2Homo sapiens (human)
Ribonucleoside-diphosphate reductase large subunitEC 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunitHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2EC 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunitHomo sapiens (human)
Deoxycytidylate deaminaseEC 3.5.4.12; dCMP deaminaseHomo sapiens (human)
ThioredoxinTrx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASPHomo sapiens (human)
Thymidylate kinaseEC 2.7.4.9; dTMP kinaseHomo sapiens (human)
Thioredoxin reductase 1, cytoplasmicTR; EC 1.8.1.9; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1Homo sapiens (human)
Adenylate kinase 2, mitochondrialAK 2; EC 2.7.4.3; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; Adenylate monophosphate kinaseHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2 BEC 1.17.4.1; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2Homo sapiens (human)
dCTP pyrophosphatase 1EC 3.6.1.12; Deoxycytidine-triphosphatase 1; dCTPase 1; RS21C6; XTP3-transactivated gene A proteinHomo sapiens (human)
Adenylate kinase isoenzyme 6AK6; EC 2.7.4.3; Adrenal gland protein AD-004; Coilin-interacting nuclear ATPase protein; hCINAP; Dual activity adenylate kinase/ATPase; AK/ATPaseHomo sapiens (human)
CTP synthase 1EC 6.3.4.2; CTP synthetase 1; UTP--ammonia ligase 1Homo sapiens (human)
CTP synthase 2EC 6.3.4.2; CTP synthetase 2; UTP--ammonia ligase 2Homo sapiens (human)
NAD(P)H pyrophosphatase NUDT13, mitochondrialEC 3.6.1.22; Nucleoside diphosphate-linked moiety X motif 13; Nudix motif 13; Protein KiSS-16Homo sapiens (human)

Compounds (26)

CompoundDescription
hydronium ion
Ammonium
IronA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Orthophosphate
Glutathione DisulfideA GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Uridine TriphosphateUridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
dihydrofolateRN given refers to (L)-isomer
diadenosine 5',5''''-P1,P6-hexaphosphateinhibits the action of ribonuceotide reductase on ADP
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Thymidine Monophosphate5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
Cytidine TriphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
Deoxycytidine MonophosphateDeoxycytidine (dihydrogen phosphate). A deoxycytosine nucleotide containing one phosphate group esterified to the deoxyribose moiety in the 2'-,3'- or 5- positions.
2'-deoxyuridylic acidRN given refers to parent cpd
adenosine 5'-tetraphosphate
deoxyuridine triphosphate
deoxyadenosine diphosphateRN given refers to parent cpd.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
5-iodocytosine deoxyribonucleoside triphosphate