Page last updated: 2024-10-06

Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

Proteins (3)

ProteinSynonymsTaxonomy
Hydroxyacid-oxoacid transhydrogenase, mitochondrialHOT; EC 1.1.99.24; Alcohol dehydrogenase iron-containing protein 1; ADHFe1; Fe-containing alcohol dehydrogenaseHomo sapiens (human)
L-2-hydroxyglutarate dehydrogenase, mitochondrialEC 1.1.99.2; DuraninHomo sapiens (human)
D-2-hydroxyglutarate dehydrogenase, mitochondrialEC 1.1.99.-Homo sapiens (human)

Compounds (9)

CompoundDescription
cobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
4-hydroxybutyric acidwas an entry term to Sodium Oxybate (74-98)
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
1,5-dihydro-FADchromophore component of E coli DNA photolyase
alpha-Ketoglutarate
alpha-hydroxyglutarate, (l)-isomer
d-2-hydroxyglutarate
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)