Page last updated: 2024-10-06

Integrated breast cancer pathway

Proteins (98)

ProteinSynonymsTaxonomy
Phosphatidylinositol 3-kinase regulatory subunit betaPI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PI3-kinase subunit p85-beta; PtdIns-3-kinase regulatory subunit p85-betaHomo sapiens (human)
Nucleic acid dioxygenase ALKBH1EC 1.14.11.-; Alkylated DNA repair protein alkB homolog 1; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA 6mA demethylase; DNA N6-methyl adenine demethylase ALKBH1; 1.14.11.51; DNA lyase ABH1; 4.2.99.18; DNA oxidative demethylase ALKBH1; 1.14.11.33; Homo sapiens (human)
Serine/threonine-protein kinase Chk1EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1Homo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16Homo sapiens (human)
Epidermal growth factor receptorEC 2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1Homo sapiens (human)
Interstitial collagenaseEC 3.4.24.7; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Androgen receptorDihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4Homo sapiens (human)
Serine/threonine-protein kinase B-rafEC 2.7.11.1; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1Homo sapiens (human)
G1/S-specific cyclin-D1B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogeneHomo sapiens (human)
Cyclin-dependent kinase 2EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinaseHomo sapiens (human)
RAC-alpha serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alphaHomo sapiens (human)
Serine/threonine-protein kinase PLK1EC 2.7.11.21; Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13; STPK13Homo sapiens (human)
Serine/threonine-protein kinase PAK 1EC 2.7.11.1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAKHomo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1Homo sapiens (human)
NAD-dependent protein deacetylase sirtuin-1hSIRT1; EC 2.3.1.286; NAD-dependent protein deacylase sirtuin-1; 2.3.1.-; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2Homo sapiens (human)
DNA mismatch repair protein Msh6hMSH6; G/T mismatch-binding protein; GTBP; GTMBP; MutS protein homolog 6; MutS-alpha 160 kDa subunit; p160Homo sapiens (human)
Double-strand break repair protein MRE11EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog AHomo sapiens (human)
Ceramide kinasehCERK; EC 2.7.1.138; Acylsphingosine kinase; Lipid kinase 4; LK4Homo sapiens (human)
DNA dC->dU-editing enzyme APOBEC-3GEC 3.5.4.-; APOBEC-related cytidine deaminase; APOBEC-related protein; ARCD; APOBEC-related protein 9; ARP-9; CEM-15; CEM15; Deoxycytidine deaminase; A3GHomo sapiens (human)
Serine/threonine-protein kinase Chk2EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2Homo sapiens (human)
Apoptosis regulator Bcl-2Homo sapiens (human)
Cyclin-dependent kinase 4EC 2.7.11.22; Cell division protein kinase 4; PSK-J3Homo sapiens (human)
Tyrosine-protein kinase FerEC 2.7.10.2; Feline encephalitis virus-related kinase FER; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Proto-oncogene c-Fer; Tyrosine kinase 3; p94-FerHomo sapiens (human)
Tyrosine-protein kinase JAK1EC 2.7.10.2; Janus kinase 1; JAK-1Homo sapiens (human)
M-phase inducer phosphatase 2EC 3.1.3.48; Dual specificity phosphatase Cdc25BHomo sapiens (human)
TGF-beta receptor type-1TGFR-1; EC 2.7.11.30; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beHomo sapiens (human)
Glycogen synthase kinase-3 alphaGSK-3 alpha; EC 2.7.11.26; Serine/threonine-protein kinase GSK3A; 2.7.11.1Homo sapiens (human)
BH3-interacting domain death agonistp22 BID; BIDHomo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
DNA repair protein RAD51 homolog 1HsRAD51; hRAD51; RAD51 homolog AHomo sapiens (human)
Bcl2-associated agonist of cell death BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell deathHomo sapiens (human)
Homeodomain-interacting protein kinase 2hHIPk2; EC 2.7.11.1Homo sapiens (human)
DNA mismatch repair protein Msh2hMSH2; MutS protein homolog 2Homo sapiens (human)
Protein kinase C-binding protein 1Cutaneous T-cell lymphoma-associated antigen se14-3; CTCL-associated antigen se14-3; Rack7; Zinc finger MYND domain-containing protein 8Homo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 16EC 3.4.19.12; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-processing protease UBP-M; Ubiquitin-specific-processing protease 16Homo sapiens (human)
Cyclic AMP-dependent transcription factor ATF-1cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; Protein TREB36Homo sapiens (human)
Nuclear factor NF-kappa-B p105 subunitDNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Homo sapiens (human)
TGF-beta receptor type-2TGFR-2; EC 2.7.11.30; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-IIHomo sapiens (human)
Protein maxClass D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor XHomo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
Bcl-2 homologous antagonist/killerApoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7Homo sapiens (human)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENEC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Mutated in multiple advanced cancers 1; Phosphatase and tensin homologHomo sapiens (human)
NEDD8-conjugating enzyme UBE2FEC 2.3.2.32; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 FHomo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 15EC 3.4.19.12; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4Homo sapiens (human)
E3 SUMO-protein ligase PIAS1EC 2.3.2.-; DEAD/H box-binding protein 1; E3 SUMO-protein transferase PIAS1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding proteinHomo sapiens (human)
Myc proto-oncogene proteinClass E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64Homo sapiens (human)
Retinoblastoma-associated protein p105-Rb; p110-RB1; pRb; Rb; pp110Homo sapiens (human)
Wee1-like protein kinaseWEE1hu; EC 2.7.10.2; Wee1A kinaseHomo sapiens (human)
M-phase inducer phosphatase 1EC 3.1.3.48; Dual specificity phosphatase Cdc25AHomo sapiens (human)
Catenin beta-1Beta-cateninHomo sapiens (human)
Breast cancer type 1 susceptibility proteinEC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1Homo sapiens (human)
Signal transducer and activator of transcription 1-alpha/betaTranscription factor ISGF-3 components p91/p84Homo sapiens (human)
Bloom syndrome proteinEC 3.6.4.12; DNA helicase, RecQ-like type 2; RecQ2; RecQ protein-like 3Homo sapiens (human)
Transcription factor E2F1E2F-1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1Homo sapiens (human)
Myelin transcription factor 1MyT1; Myelin transcription factor I; MyTI; PLPB1; Proteolipid protein-binding proteinHomo sapiens (human)
Serine-protein kinase ATMEC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutatedHomo sapiens (human)
Serine/threonine-protein kinase ATREC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1Homo sapiens (human)
Bone morphogenetic protein receptor type-2BMP type-2 receptor; BMPR-2; EC 2.7.11.30; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-IIHomo sapiens (human)
Mothers against decapentaplegic homolog 2MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2Homo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 21EC 3.4.19.12; Deubiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21Homo sapiens (human)
Transcription regulator protein BACH1BTB and CNC homolog 1; HA2303Homo sapiens (human)
Mothers against decapentaplegic homolog 7MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7Homo sapiens (human)
Mothers against decapentaplegic homolog 6MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6Homo sapiens (human)
FAS-associated death domain proteinFAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; Protein FADDHomo sapiens (human)
Mothers against decapentaplegic homolog 4MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4Homo sapiens (human)
Mothers against decapentaplegic homolog 1MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein 1; BSP-1Homo sapiens (human)
Mitogen-activated protein kinase kinase kinase 13EC 2.7.11.25; Leucine zipper-bearing kinase; Mixed lineage kinase; MLKHomo sapiens (human)
Serine/threonine-protein kinase A-RafEC 2.7.11.1; Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene PksHomo sapiens (human)
Transcription activator BRG1EC 3.6.4.-; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfHomo sapiens (human)
GTP-binding protein RhebRas homolog enriched in brainHomo sapiens (human)
Polymeric immunoglobulin receptorPIgR; Poly-Ig receptor; Hepatocellular carcinoma-associated protein TB6Homo sapiens (human)
Ras-related protein Ral-AEC 3.6.5.2Homo sapiens (human)
Protein PMLPromyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19Homo sapiens (human)
Filamin-A-interacting protein 1FILIPHomo sapiens (human)
Tumor necrosis factor receptor superfamily member EDARAnhidrotic ectodysplasin receptor 1; Downless homolog; EDA-A1 receptor; Ectodermal dysplasia receptor; Ectodysplasin-A receptorHomo sapiens (human)
DNA repair protein RAD50hRAD50; EC 3.6.-.-Homo sapiens (human)
Putative aquaporin-7-like protein 3Homo sapiens (human)
Ras-related protein R-RasEC 3.6.5.-; p23Homo sapiens (human)
Nucleoprotein TPRMegator; NPC-associated intranuclear protein; Translocated promoter region proteinHomo sapiens (human)
Fos-related antigen 2 FRA-2Homo sapiens (human)
NeurofibrominNeurofibromatosis-related protein NF-1Homo sapiens (human)
MAP3K7 C-terminal-like proteinTAK1-like proteinHomo sapiens (human)
cAMP-dependent protein kinase inhibitor alphaPKI-alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoformHomo sapiens (human)
NGFI-A-binding protein 1EGR-1-binding protein 1; Transcriptional regulatory protein p54Homo sapiens (human)
Tumor necrosis factor receptor type 1-associated DEATH domain proteinTNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domainHomo sapiens (human)
NADPH oxidase activator 1NOX activator 1; Antigen NY-CO-31; NCF2-like protein; P67phox-like factor; p51-noxHomo sapiens (human)
Zinc finger protein 655Vav-interacting Krueppel-like proteinHomo sapiens (human)
Dephospho-CoA kinase domain-containing proteinHomo sapiens (human)
HamartinTuberous sclerosis 1 proteinHomo sapiens (human)
Janus kinase and microtubule-interacting protein 1GABA-B receptor-binding protein; Multiple alpha-helices and RNA-linker protein 1; Marlin-1Homo sapiens (human)
E3 ubiquitin-protein ligase CCNB1IP1EC 2.3.2.27; Cyclin-B1-interacting protein 1; Human enhancer of invasion 10; RING-type E3 ubiquitin transferase CCNB1IP1Homo sapiens (human)
Galactoside-binding soluble lectin 13Galectin-13; Gal-13; Placental tissue protein 13; PP13; Placental protein 13Homo sapiens (human)
Zinc finger MIZ domain-containing protein 1PIAS-like protein Zimp10; Retinoic acid-induced protein 17Homo sapiens (human)
Cation-transporting ATPase Homo sapiens (human)
Selenoprotein KSelKHomo sapiens (human)
Ubiquitin-like protein FUBIHomo sapiens (human)

Compounds (17)

CompoundDescription
fulvestrantAn estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.
lapatinibA quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (RECEPTOR, ERBB-2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2.
tamoxifenOne of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
donepezilAn indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
flutamideAn antiandrogen with about the same potency as cyproterone in rodent and canine species.
hydroxyureaAn antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
lithium chlorideA salt of lithium that has been used experimentally as an immunomodulator.
BleomycinA complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid.
EstradiolThe 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
ampicillinSemi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
dihydrotestosteroneA potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.
tetradecanoylphorbol acetateA phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
nocodazoleNocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.
methyl methanesulfonateAn alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA.
cycloheximideAntibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
corticosteroneAn adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)