Insulin receptor signalling cascade

Proteins (9)

Protein	Synonyms	Taxonomy
3-phosphoinositide-dependent protein kinase 1	hPDK1; EC 2.7.11.1	Homo sapiens (human)
Insulin receptor	IR; EC 2.7.10.1	Homo sapiens (human)
RAC-beta serine/threonine-protein kinase	EC 2.7.11.1; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta	Homo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alpha	PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha	Homo sapiens (human)
SHC-transforming protein 1	SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1	Homo sapiens (human)
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	EC 3.1.4.17; CGIPDE1; CGIP1; Cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B	Homo sapiens (human)
Growth factor receptor-bound protein 10	GRB10 adapter protein; Insulin receptor-binding protein Grb-IR	Homo sapiens (human)
Insulin		Homo sapiens (human)
Son of sevenless homolog 1	SOS-1	Homo sapiens (human)

Compound	Description
Orthophosphate
adenosine diphosphate	Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Guanosine Monophosphate	A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine Diphosphate	A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
adenosine monophosphate	Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
adenosine triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
cyclic amp	An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.