Page last updated: 2024-10-06

IL6-mediated signaling events

Proteins (45)

ProteinSynonymsTaxonomy
Tumor necrosis factor ligand superfamily member 11Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCEHomo sapiens (human)
Tyrosine-protein kinase JAK2EC 2.7.10.2; Janus kinase 2; JAK-2Homo sapiens (human)
Tyrosine-protein kinase HCKEC 2.7.10.2; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61HckHomo sapiens (human)
Non-receptor tyrosine-protein kinase TYK2EC 2.7.10.2Homo sapiens (human)
RAC-alpha serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alphaHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 6MAP kinase kinase 6; MAPKK 6; EC 2.7.12.2; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3Homo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 11EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3Homo sapiens (human)
Bcl-2-like protein 1Bcl2-L-1; Apoptosis regulator Bcl-XHomo sapiens (human)
Induced myeloid leukemia cell differentiation protein Mcl-1Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EATHomo sapiens (human)
Mitogen-activated protein kinase 14MAP kinase 14; MAPK 14; EC 2.7.11.24; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Tyrosine-protein kinase JAK1EC 2.7.10.2; Janus kinase 1; JAK-1Homo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
Signal transducer and activator of transcription 3Acute-phase response factorHomo sapiens (human)
Growth factor receptor-bound protein 2Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2Homo sapiens (human)
Protein kinase C delta typeEC 2.7.11.13; Tyrosine-protein kinase PRKCD; 2.7.10.2; nPKC-deltaHomo sapiens (human)
Metalloproteinase inhibitor 1Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase epsilonProtein-tyrosine phosphatase epsilon; R-PTP-epsilon; EC 3.1.3.48Homo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
E3 SUMO-protein ligase PIAS1EC 2.3.2.-; DEAD/H box-binding protein 1; E3 SUMO-protein transferase PIAS1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding proteinHomo sapiens (human)
Myc proto-oncogene proteinClass E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64Homo sapiens (human)
Interleukin-6IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2Homo sapiens (human)
Signal transducer and activator of transcription 1-alpha/betaTranscription factor ISGF-3 components p91/p84Homo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 4MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKKHomo sapiens (human)
Forkhead box protein O1Forkhead box protein O1A; Forkhead in rhabdomyosarcomaHomo sapiens (human)
Proto-oncogene vavHomo sapiens (human)
Alpha-2-macroglobulinAlpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5Homo sapiens (human)
CCAAT/enhancer-binding protein betaC/EBP beta; Liver activator protein; LAP; Liver-enriched inhibitory protein; LIP; Nuclear factor NF-IL6; Transcription factor 5; TCF-5Homo sapiens (human)
Proto-oncogene c-FosCellular oncogene fos; G0/G1 switch regulatory protein 7Homo sapiens (human)
Interleukin-6 receptor subunit alphaIL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80Homo sapiens (human)
Endoplasmin94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homologHomo sapiens (human)
Interleukin-6 receptor subunit betaIL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alphaHomo sapiens (human)
Microphthalmia-associated transcription factorClass E basic helix-loop-helix protein 32; bHLHe32Homo sapiens (human)
Lipopolysaccharide-binding proteinLBPHomo sapiens (human)
C-reactive proteinHomo sapiens (human)
Interferon regulatory factor 1IRF-1Homo sapiens (human)
E3 SUMO-protein ligase PIAS3EC 2.3.2.-; E3 SUMO-protein transferase PIAS3; Protein inhibitor of activated STAT protein 3Homo sapiens (human)
CCAAT/enhancer-binding protein deltaC/EBP delta; Nuclear factor NF-IL6-beta; NF-IL6-betaHomo sapiens (human)
Suppressor of cytokine signaling 3SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3Homo sapiens (human)
Fibrinogen gamma chainHomo sapiens (human)
Alpha-1B-glycoproteinAlpha-1-B glycoproteinHomo sapiens (human)
Transcription factor jun-BHomo sapiens (human)
LIM domain transcription factor LMO4Breast tumor autoantigen; LIM domain only protein 4; LMO-4Homo sapiens (human)

Compounds (0)

CompoundDescription