Page last updated: 2024-10-06

Histidine biosynthesis I

Proteins (7)

ProteinSynonymsTaxonomy
ATP phosphoribosyltransferase, chloroplasticATP-PRTase; AtATP-PRT; EC 2.4.2.17Oryza sativa Japonica Group (Japanese rice)
Histidinol dehydrogenase, chloroplasticHDH; EC 1.1.1.23Oryza sativa Japonica Group (Japanese rice)
Histidinol-phosphatase Oryza sativa Japonica Group (Japanese rice)
1-Oryza sativa Indica Group (long-grained rice)
Phosphoribosyl-AMP cyclohydrolase Oryza sativa Japonica Group (Japanese rice)
Imidazoleglycerol-phosphate dehydratase Oryza sativa (Asian cultivated rice)
Os02g0709200 protein Oryza sativa Japonica Group (Japanese rice)

Compounds (13)

CompoundDescription
NADH
Orthophosphate
phosphoribosyl pyrophosphateThe key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
alpha-Ketoglutarate
n(1)-((5'-phosphoribulosyl)formimino)-5-aminoimidazo-4-carboxamide ribonucleotidestructure given in first source; an intermediate in imidazole glycerol phosphate synthesis
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
histidinalan intermediate in the conversion of L-histidinol to L-istidine by histidinol dehydrogenase; RN given refers to (S)-isomer
histidinolThe penultimate step in the pathway of histidine biosynthesis. Oxidation of the alcohol group on the side chain gives the acid group forming histidine. Histidinol has also been used as an inhibitor of protein synthesis.
AICA ribonucleotidepurine precursor that has antineoplastic activity