Pathways > Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) )
Page last updated: 2024-10-06

Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) )

Proteins (18)

ProteinSynonymsTaxonomy
Serine/threonine-protein kinase B-raf EC 2.7.11.1; Proto-oncogene B-RafMus musculus (house mouse)
Proto-oncogene tyrosine-protein kinase Src EC 2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-SrcRattus norvegicus (Norway rat)
Guanine nucleotide-binding protein G(i) subunit alpha-2Adenylate cyclase-inhibiting G alpha proteinRattus norvegicus (Norway rat)
Adenosine receptor A3TGPCR1Rattus norvegicus (Norway rat)
Rap guanine nucleotide exchange factor 1CRK SH3-binding GNRP; Guanine nucleotide-releasing factor 2; Protein C3GHomo sapiens (human)
Adenylate cyclase type 4EC 4.6.1.1; ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4Homo sapiens (human)
Regulator of G-protein signaling 13RGS13Mus musculus (house mouse)
Crk-like proteinMus musculus (house mouse)
Ras-related protein Rap-1AEC 3.6.5.2; Ras-related protein Krev-1Rattus norvegicus (Norway rat)
cAMP-dependent protein kinase type I regulatory subunitDRI class I to class IVDrosophila melanogaster (fruit fly)
Mitogen-activated protein kinase ERK-AEC 2.7.11.24; Extracellular-regulated kinase A; Protein rolledDrosophila melanogaster (fruit fly)
Guanine nucleotide-binding protein subunit beta-5Gbeta5; Transducin beta chain 5Rattus norvegicus (Norway rat)
cAMP-dependent protein kinase catalytic subunit betaPKA C-beta; EC 2.7.11.11Rattus norvegicus (Norway rat)
Dual specificity mitogen-activated protein kinase kinase mek-2MAP kinase kinase mek-2; EC 2.7.12.2Caenorhabditis elegans
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2G gamma-C; G-gamma-8Mus musculus (house mouse)
E3 ubiquitin-protein ligase CBL-CEC 2.3.2.27; RING finger protein 57; RING-type E3 ubiquitin transferase CBL-C; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-CHomo sapiens (human)
Cholera enterotoxin subunit ACholera enterotoxin, A chainVibrio cholerae O1 biovar El Tor str. N16961
Guanine nucleotide-binding protein GAdenylate cyclase-stimulating G alpha protein; G-alpha-8Rattus norvegicus (Norway rat)

Compounds (4)

CompoundDescription
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
guanosine triphosphateGuanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.
Cyclic AMPAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.