Page last updated: 2024-10-06

Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta) ( GPCR GroupI metabotropic glutamate receptor signaling pathway )

Proteins (10)

ProteinSynonymsTaxonomy
Metabotropic glutamate receptor 5mGluR5Rattus norvegicus (Norway rat)
Inositol 1,4,5-trisphosphate receptor type 3IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptorRattus norvegicus (Norway rat)
Protein kinase C delta typeEC 2.7.11.13; nPKC-deltaRattus norvegicus (Norway rat)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2EC 3.1.4.11; Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2Rattus norvegicus (Norway rat)
Mitogen-activated protein kinase ERK-AEC 2.7.11.24; Extracellular-regulated kinase A; Protein rolledDrosophila melanogaster (fruit fly)
Guanine nucleotide-binding protein subunit beta-5Gbeta5; Transducin beta chain 5Rattus norvegicus (Norway rat)
Guanine nucleotide-binding protein G(q) subunit alphaGuanine nucleotide-binding protein alpha-qRattus norvegicus (Norway rat)
Raf homolog serine/threonine-protein kinaseEC 2.7.11.1; Abnormal cell lineage protein 45Caenorhabditis elegans
Dual specificity mitogen-activated protein kinase kinase mek-2MAP kinase kinase mek-2; EC 2.7.12.2Caenorhabditis elegans
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2G gamma-C; G-gamma-8Mus musculus (house mouse)

Compounds (4)

CompoundDescription
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
guanosine triphosphateGuanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.
inositol 1,4,5-trisphosphateIntracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.