Pathways > Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) )
Page last updated: 2024-10-06

Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) )

Proteins (13)

ProteinSynonymsTaxonomy
Serine/threonine-protein kinase B-raf EC 2.7.11.1; Proto-oncogene B-RafMus musculus (house mouse)
Guanine nucleotide-binding protein G(i) subunit alpha-2Adenylate cyclase-inhibiting G alpha proteinRattus norvegicus (Norway rat)
Adenosine receptor A3TGPCR1Rattus norvegicus (Norway rat)
Adenylate cyclase type 4EC 4.6.1.1; ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4Homo sapiens (human)
Regulator of G-protein signaling 13RGS13Mus musculus (house mouse)
Ras-related protein Rap-1AEC 3.6.5.2; Ras-related protein Krev-1Rattus norvegicus (Norway rat)
Mitogen-activated protein kinase ERK-AEC 2.7.11.24; Extracellular-regulated kinase A; Protein rolledDrosophila melanogaster (fruit fly)
Guanine nucleotide-binding protein subunit beta-5Gbeta5; Transducin beta chain 5Rattus norvegicus (Norway rat)
Dual specificity mitogen-activated protein kinase kinase mek-2MAP kinase kinase mek-2; EC 2.7.12.2Caenorhabditis elegans
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2G gamma-C; G-gamma-8Mus musculus (house mouse)
Rap guanine nucleotide exchange factor 3 Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFIMus musculus (house mouse)
Cholera enterotoxin subunit ACholera enterotoxin, A chainVibrio cholerae O1 biovar El Tor str. N16961
Guanine nucleotide-binding protein GAdenylate cyclase-stimulating G alpha protein; G-alpha-8Rattus norvegicus (Norway rat)

Compounds (4)

CompoundDescription
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
guanosine triphosphateGuanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.
Cyclic AMPAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.