Pathways > HMOX1 pathway (COVID-19 Disease Map)
Page last updated: 2024-10-06

HMOX1 pathway (COVID-19 Disease Map)

Proteins (36)

ProteinSynonymsTaxonomy
Ferrochelatase, mitochondrialEC 4.99.1.1; Heme synthase; Protoheme ferro-lyaseHomo sapiens (human)
Flavin reductase (NADPH)FR; EC 1.5.1.30; Biliverdin reductase B; BVR-B; 1.3.1.24; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; FLRHomo sapiens (human)
Phospholipid hydroperoxide glutathione peroxidasePHGPx; EC 1.11.1.12; Glutathione peroxidase 4; GPx-4; GSHPx-4Homo sapiens (human)
Nuclear receptor coactivator 4NCoA-4; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1Homo sapiens (human)
Amyloid-beta precursor proteinAPP; ABPP; APPI; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta A4 protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-IIHomo sapiens (human)
Heat shock protein HSP 90-betaHSP 90; Heat shock 84 kDa; HSP 84; HSP84Homo sapiens (human)
Cathepsin GCG; EC 3.4.21.20Homo sapiens (human)
Nuclear factor erythroid 2-related factor 2NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; HEBP1; Nuclear factor, erythroid derived 2, like 2Homo sapiens (human)
Broad substrate specificity ATP-binding cassette transporter ABCG2EC 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporterHomo sapiens (human)
Uroporphyrinogen decarboxylaseUPD; URO-D; EC 4.1.1.37Homo sapiens (human)
AlbuminHomo sapiens (human)
SerotransferrinTransferrin; Beta-1 metal-binding globulin; SiderophilinHomo sapiens (human)
Heme oxygenase 1HO-1; EC 1.14.14.18Homo sapiens (human)
Caspase-1CASP-1; EC 3.4.22.36; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Homo sapiens (human)
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrialCOX; Coprogen oxidase; Coproporphyrinogenase; EC 1.3.3.3Homo sapiens (human)
Natural resistance-associated macrophage protein 2NRAMP 2; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; Solute carrier family 11 member 2Homo sapiens (human)
NACHT, LRR and PYD domains-containing protein 3 Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1Homo sapiens (human)
Mucolipin-1ML1; MG-2; Mucolipidin; Transient receptor potential channel mucolipin 1; TRPML1Homo sapiens (human)
Interleukin-1 betaIL-1 beta; CatabolinHomo sapiens (human)
ThioredoxinTrx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASPHomo sapiens (human)
Kelch-like ECH-associated protein 1Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19Homo sapiens (human)
Uroporphyrinogen-III synthaseUROIIIS; UROS; EC 4.2.1.75; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthaseHomo sapiens (human)
Transcription regulator protein BACH1BTB and CNC homolog 1; HA2303Homo sapiens (human)
Transferrin receptor protein 1TR; TfR; TfR1; Trfr; T9; p90Homo sapiens (human)
Interleukin-18IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gammaHomo sapiens (human)
Apoptosis-associated speck-like protein containing a CARDhASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1Homo sapiens (human)
ORF3a proteinORF3a; Accessory protein 3a; Protein 3a; Protein U274; Protein X1Severe acute respiratory syndrome coronavirus 2
Transcription factor MafProto-oncogene c-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homologHomo sapiens (human)
Thioredoxin-interacting proteinThioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1Homo sapiens (human)
Proline-serine-threonine phosphatase-interacting protein 1PEST phosphatase-interacting protein 1; CD2-binding protein 1; H-PIPHomo sapiens (human)
Metalloreductase STEAP3EC 1.16.1.-; Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHydeHomo sapiens (human)
Cullin-associated NEDD8-dissociated protein 1Cullin-associated and neddylation-dissociated protein 1; TBP-interacting protein of 120 kDa A; TBP-interacting protein 120A; p120 CAND1Homo sapiens (human)
Protein SGT1 homologProtein 40-6-3; Sgt1; Suppressor of G2 allele of SKP1 homologHomo sapiens (human)
Feline leukemia virus subgroup C receptor-related protein 1Feline leukemia virus subgroup C receptor; hFLVCRHomo sapiens (human)
ORF3a proteinAccessory protein 3a; Protein 3a; Protein U274; Protein X1Severe acute respiratory syndrome-related coronavirus
Envelope small membrane proteinE protein; sM proteinSevere acute respiratory syndrome-related coronavirus

Compounds (26)

CompoundDescription
hydronium ion
Orthophosphate
Ammonium
Silicon DioxideTransparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
carbon monoxideCarbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
IronA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
leadA soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
dimethyl fumarateA fumarate derivative that is used as a DERMATOLOGIC AGENT in the treatment of PSORIASIS and SKIN DISEASES. It also may be used as an IMMUNOSUPPRESSIVE AGENT in the treatment of MULTIPLE SCLEROSIS.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
succinyl-coenzyme A
preuroporphyrinogen
uroporphyrinogen iii
protoporphyrinogen
coproporphyrinogen iii
protoporphyrin ixRN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
bilirubinA bile pigment that is a degradation product of HEME.
Biliverdine1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone. Biosynthesized from hemoglobin as a precursor of bilirubin. Occurs in the bile of AMPHIBIANS and of birds, but not in normal human bile or serum.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Porphobilinogen
creolinfrom refined coal tar oils
coenzyme a
chemdatabank.com