Page last updated: 2024-10-06

Glyoxylate metabolism and glycine degradation

Proteins (20)

ProteinSynonymsTaxonomy
Hydroxyacid oxidase 1HAOX1; EC 1.1.3.15; Glycolate oxidase; GOXHomo sapiens (human)
Aspartate aminotransferase, mitochondrialmAspAT; EC 2.6.1.1; EC 2.6.1.7; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; PlHomo sapiens (human)
Serine--pyruvate aminotransferaseSPT; EC 2.6.1.51; Alanine--glyoxylate aminotransferase; AGT; 2.6.1.44Homo sapiens (human)
Hydroxyproline dehydrogenaseHYPDH; EC 1.5.5.3; Kidney and liver proline oxidase 1; HsPOX1; Probable proline dehydrogenase 2; 1.5.5.2; Probable proline oxidase 2Homo sapiens (human)
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialP5C dehydrogenase; EC 1.2.1.88; Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenaseHomo sapiens (human)
D-amino-acid oxidaseDAAO; DAMOX; DAO; EC 1.4.3.3Homo sapiens (human)
D-aspartate oxidaseDASOX; DDO; EC 1.4.3.1Homo sapiens (human)
Glyoxylate reductase/hydroxypyruvate reductaseEC 1.1.1.79; EC 1.1.1.81Homo sapiens (human)
4-hydroxy-2-oxoglutarate aldolase, mitochondrialEC 4.1.3.16; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; Protein 569272Homo sapiens (human)
Acyl carrier protein, mitochondrialACP; CI-SDAP; NADH-ubiquinone oxidoreductase 9.6 kDa subunitHomo sapiens (human)
Glycine N-methyltransferaseEC 2.1.1.20Homo sapiens (human)
Dihydrolipoyl dehydrogenase, mitochondrialEC 1.8.1.4; Dihydrolipoamide dehydrogenase; Glycine cleavage system L proteinHomo sapiens (human)
Lipoyl synthase, mitochondrialEC 2.8.1.8; Lipoate synthase; LS; Lip-syn; Lipoic acid synthaseHomo sapiens (human)
Lipoyltransferase 1, mitochondrialEC 2.3.1.-; Lipoate biosynthesis protein; Lipoate-protein ligase; Lipoyl ligaseHomo sapiens (human)
Putative lipoyltransferase 2, mitochondrialEC 2.3.1.181; Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferaseHomo sapiens (human)
Glycine dehydrogenase (decarboxylating), mitochondrialEC 1.4.4.2; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring)Homo sapiens (human)
Glycine cleavage system H protein, mitochondrialLipoic acid-containing proteinHomo sapiens (human)
Aminomethyltransferase, mitochondrialEC 2.1.2.10; Glycine cleavage system T protein; GCVTHomo sapiens (human)
Alanine--glyoxylate aminotransferase 2, mitochondrialAGT 2; EC 2.6.1.44; (R)-3-amino-2-methylpropionate--pyruvate transaminase; 2.6.1.40; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBATHomo sapiens (human)
Peroxisomal membrane protein 222 kDa peroxisomal membrane proteinHomo sapiens (human)

Compounds (26)

CompoundDescription
hydronium ion
NADH
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
Ammonium
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
hydrogen sulfideA flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
Aspartate
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
5,6,7,8-tetrahydrofolic acidRN given refers to (DL)-isomer
5,10-methylenetetrahydrofolate
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
OxaloacetateAn anionic form of oxaloacetic acid.
5'-deoxyadenosinemain heading DEOXYADENOSINE refers to the 3' cpd
2-keto-4-hydroxyglutarateRN given refers to parent cpd
glycolate
cocobetaineN-alkyl-betaine; cause of shampoo dermatitis
glyoxylic acidRN given refers to parent cpd
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
creolinfrom refined coal tar oils
d-aspartic acidThe D-isomer of ASPARTIC ACID.
oxalic acidA strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.