Pathways > Glycerophospholipid biosynthetic pathway
Page last updated: 2024-10-06

Glycerophospholipid biosynthetic pathway

Proteins (32)

ProteinSynonymsTaxonomy
Inositol polyphosphate multikinaseEC 2.7.1.140; EC 2.7.1.151; EC 2.7.1.153; Inositol 1,3,4,6-tetrakisphosphate 5-kinaseHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110deltaHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; EC 2.7.1.137; EC 2.7.1.153; EC 2.7.1.154; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PtdIns-3-kinase subunit p110-gamma; p110gamma; PhosphHomo sapiens (human)
Dihydroxyacetone phosphate acyltransferaseDAP-AT; DHAP-AT; EC 2.3.1.42; Acyl-CoA:dihydroxyacetonephosphateacyltransferase; Glycerone-phosphate O-acyltransferaseHomo sapiens (human)
Glycerol-3-phosphate acyltransferase 4EC 2.3.1.15; 1-acylglycerol-3-phosphate O-acyltransferase 6; 1-AGP acyltransferase 6; 1-AGPAT 6; Acyl-CoA:glycerol-3-phosphate acyltransferase 4; Lysophosphatidic acid acyltransferase zeta; LPAAT-zeta; Testis spermatogenesis apoptosis-related protein 7; THomo sapiens (human)
Choline/ethanolaminephosphotransferase 1hCEPT1; EC 2.7.8.1; EC 2.7.8.2Homo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPI3-kinase subunit beta; PI3K-beta; PI3Kbeta; PtdIns-3-kinase subunit beta; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110betaHomo sapiens (human)
Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaPIP5K1-alpha; PtdIns(4)P-5-kinase 1 alpha; EC 2.7.1.68; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; PIP5KIalphaHomo sapiens (human)
Glycerol kinaseGK; Glycerokinase; EC 2.7.1.30; ATP:glycerol 3-phosphotransferaseHomo sapiens (human)
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1EC 3.1.3.27; PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1; 3.1.3.16; 3.1.3.48Homo sapiens (human)
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicGPD-C; GPDH-C; EC 1.1.1.8Homo sapiens (human)
Choline/ethanolamine kinaseCholine kinase beta; CK; CKB; 2.7.1.32; Choline kinase-like protein; Ethanolamine kinase; EK; 2.7.1.82; Ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKBHomo sapiens (human)
Glycerol-3-phosphate acyltransferase 3GPAT-3; EC 2.3.1.15; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; AGPAT 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 1-AGP acyltransferase 9; 1-AGPAT 9; 2.3.1.51; Acyl-CoA:glycerol-3-phosphate acyltransferase 3; hGPAT3; Lung cancer metaHomo sapiens (human)
Phospholipase A2, membrane associatedEC 3.1.1.4; GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2AHomo sapiens (human)
2-acylglycerol O-acyltransferase 3EC 2.3.1.20; EC 2.3.1.22; Acyl-CoA:monoacylglycerol acyltransferase 3; MGAT3; Diacylglycerol O-acyltransferase candidate 7; hDC7; Diacylglycerol acyltransferase 2-like protein 7; Monoacylglycerol O-acyltransferase 3Homo sapiens (human)
Phosphatidylinositol 4-kinase type 2-alphaEC 2.7.1.67; Phosphatidylinositol 4-kinase type II-alphaHomo sapiens (human)
Glycerol-3-phosphate acyltransferase 1, mitochondrialGPAT-1; EC 2.3.1.15Homo sapiens (human)
Alkyldihydroxyacetonephosphate synthase, peroxisomalAlkyl-DHAP synthase; EC 2.5.1.26; Aging-associated gene 5 protein; Alkylglycerone-phosphate synthaseHomo sapiens (human)
NADPH-dependent 1-acyldihydroxyacetone phosphate reductaseADR; EC 1.1.1.101; 1-acyl DHAP reductase; Acyl/alkyl DHAP reductase; Acylglycerone-phosphate reductase; Triacylglycerol lipase AYR1; TAG lipase; 3.1.1.3Saccharomyces cerevisiae S288C
Cardiolipin synthase (CMP-forming)CLS; EC 2.7.8.41; Protein GCD10 homologHomo sapiens (human)
Phosphatidylethanolamine N-methyltransferasePEAMT; PEMT; EC 2.1.1.17; EC 2.1.1.71; PEMT2; Phospholipid methyltransferase; PLMTHomo sapiens (human)
Ethanolamine-phosphate cytidylyltransferaseEC 2.7.7.14; CTP:phosphoethanolamine cytidylyltransferase; Phosphorylethanolamine transferaseHomo sapiens (human)
Cholinephosphotransferase 1EC 2.7.8.2; Aminoalcohol phosphotransferase CPT1; Diacylglycerol cholinephosphotransferase 1; Sn-1,2-diacylglycerol cholinephosphotransferase; CHOPTSaccharomyces cerevisiae S288C
Cholinephosphotransferase 1hCPT1; EC 2.7.8.2; AAPT1-like protein; Diacylglycerol cholinephosphotransferase 1Homo sapiens (human)
Glycerol-3-phosphate acyltransferase 2, mitochondrialGPAT-2; EC 2.3.1.15; 1-acylglycerol-3-phosphate O-acyltransferase GPAT2; 2.3.1.51; xGPAT1Homo sapiens (human)
Phosphatidylserine synthase 1PSS-1; PtdSer synthase 1; EC 2.7.8.29; Serine-exchange enzyme IHomo sapiens (human)
CDP-diacylglycerol--inositol 3-phosphatidyltransferaseEC 2.7.8.11; Phosphatidylinositol synthase; PI synthase; PtdIns synthaseHomo sapiens (human)
Phosphatidate cytidylyltransferase 2EC 2.7.7.41; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDS 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2Homo sapiens (human)
Phosphatidate phosphatase LPIN1EC 3.1.3.4; Lipin-1Homo sapiens (human)
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialEC 2.7.8.5; Phosphatidylglycerophosphate synthase 1; PGP synthase 1Homo sapiens (human)
Phosphatidate phosphatase LPIN2EC 3.1.3.4; Lipin-2Homo sapiens (human)

Compounds (23)

CompoundDescription
phosphorylcholineCalcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
Cytidine Diphosphate CholineDonor of choline in biosynthesis of choline-containing phosphoglycerides.
cholineA basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
glycerolA trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
inositolAn isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Coenzyme A
phosphorylethanolamineRN given refers to parent cpd; structure
cdp ethanolamine
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
serineA non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
cytidine monophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
cytidine triphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
dihydroxyacetone phosphateAn important intermediate in lipid biosynthesis and in glycolysis.
ethanolamineA viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.
alpha-glycerophosphoric acid
s-adenosylhomocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
creolinfrom refined coal tar oils
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