Pathways > Glycerophospholipid biosynthesis
Page last updated: 2024-10-06

Glycerophospholipid biosynthesis

Proteins (74)

ProteinSynonymsTaxonomy
Trifunctional enzyme subunit alpha, mitochondrial78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; 2.3.1.-; TP-alphaHomo sapiens (human)
Lysocardiolipin acyltransferase 1EC 2.3.1.-; 1-acylglycerol-3-phosphate O-acyltransferase 8; 1-AGP acyltransferase 8; 1-AGPAT 8; 2.3.1.51; Acyl-CoA:lysocardiolipin acyltransferase 1Homo sapiens (human)
AcetylcholinesteraseAChE; EC 3.1.1.7Homo sapiens (human)
Phospholipase A2 group XV1-O-acylceramide synthase; ACS; LCAT-like lysophospholipase; LLPL; 3.1.1.5; Lysophospholipase 3; Lysosomal phospholipase A and acyltransferase; 2.3.1.-; 3.1.1.32; 3.1.1.4; Lysosomal phospholipase A2; LPLA2Homo sapiens (human)
Monoglyceride lipaseMGL; EC 3.1.1.23; HU-K5; Lysophospholipase homolog; Lysophospholipase-like; Monoacylglycerol lipase; MAGLHomo sapiens (human)
Dihydroxyacetone phosphate acyltransferaseDAP-AT; DHAP-AT; EC 2.3.1.42; Acyl-CoA:dihydroxyacetonephosphateacyltransferase; Glycerone-phosphate O-acyltransferaseHomo sapiens (human)
Glycerol-3-phosphate acyltransferase 4EC 2.3.1.15; 1-acylglycerol-3-phosphate O-acyltransferase 6; 1-AGP acyltransferase 6; 1-AGPAT 6; Acyl-CoA:glycerol-3-phosphate acyltransferase 4; Lysophosphatidic acid acyltransferase zeta; LPAAT-zeta; Testis spermatogenesis apoptosis-related protein 7; THomo sapiens (human)
Trifunctional enzyme subunit beta, mitochondrialTP-betaHomo sapiens (human)
START domain-containing protein 10StARD10; Antigen NY-CO-28; PCTP-like protein; PCTP-L; Serologically defined colon cancer antigen 28; StAR-related lipid transfer protein 10Homo sapiens (human)
Group XIIA secretory phospholipase A2GXII sPLA2; sPLA2-XII; EC 3.1.1.4; Phosphatidylcholine 2-acylhydrolase 12AHomo sapiens (human)
Choline/ethanolaminephosphotransferase 1hCEPT1; EC 2.7.8.1; EC 2.7.8.2Homo sapiens (human)
Group IIF secretory phospholipase A2GIIF sPLA2; sPLA2-IIF; EC 3.1.1.4; Phosphatidylcholine 2-acylhydrolase 2FHomo sapiens (human)
Group 3 secretory phospholipase A2EC 3.1.1.4; Group III secretory phospholipase A2; GIII sPLA2; sPLA2-III; Phosphatidylcholine 2-acylhydrolase 3Homo sapiens (human)
Group IID secretory phospholipase A2GIID sPLA2; sPLA2-IID; EC 3.1.1.4; PLA2IID; Phosphatidylcholine 2-acylhydrolase 2D; Secretory-type PLA, stroma-associated homologHomo sapiens (human)
Phospholipase A2 group VEC 3.1.1.4; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5Homo sapiens (human)
Casein kinase II subunit betaCK II beta; Phosvitin; Protein G5aHomo sapiens (human)
Group 10 secretory phospholipase A2EC 3.1.1.4; Group X secretory phospholipase A2; GX sPLA2; sPLA2-X; Phosphatidylcholine 2-acylhydrolase 10Homo sapiens (human)
85/88 kDa calcium-independent phospholipase A2CaI-PLA2; EC 3.1.1.4; 2-lysophosphatidylcholine acylhydrolase; 3.1.1.5; Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; Palmitoyl-CoA hydrolase; 3.1.2.2; Patatin-like phospholipHomo sapiens (human)
Phospholipase A2EC 3.1.1.4; Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1BHomo sapiens (human)
Intestinal-type alkaline phosphataseIAP; Intestinal alkaline phosphatase; EC 3.1.3.1Homo sapiens (human)
Group IIE secretory phospholipase A2GIIE sPLA2; sPLA2-IIE; EC 3.1.1.4; Phosphatidylcholine 2-acylhydrolase 2EHomo sapiens (human)
Cytosolic phospholipase A2 gammacPLA2-gamma; EC 3.1.1.4; Cytosolic lysophospholipase; 3.1.1.5; Cytosolic lysophospholipid O-acyltransferase; 2.3.1.-; Phospholipase A2 group IVCHomo sapiens (human)
Acyl-CoA wax alcohol acyltransferase 2EC 2.3.1.75; 11-cis-specific retinyl-ester synthase; 11-cis-RE-synthase; Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Retinol O-fatty-acyltransferase; 2.3.1.76; Diacylglycerol O-acyltransferase 2-like protein 4; Diacylglycerol O-acyltransferase candidaHomo sapiens (human)
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1EC 3.1.3.27; PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1; 3.1.3.16; 3.1.3.48Homo sapiens (human)
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicGPD-C; GPDH-C; EC 1.1.1.8Homo sapiens (human)
Glycerol-3-phosphate dehydrogenase 1-like proteinGPD1-L; EC 1.1.1.8Homo sapiens (human)
Acylglycerol kinase, mitochondrialhAGK; EC 2.7.1.107; EC 2.7.1.138; EC 2.7.1.94; Multiple substrate lipid kinase; HsMuLK; MuLK; Multi-substrate lipid kinaseHomo sapiens (human)
Choline/ethanolamine kinaseCholine kinase beta; CK; CKB; 2.7.1.32; Choline kinase-like protein; Ethanolamine kinase; EK; 2.7.1.82; Ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKBHomo sapiens (human)
Phosphatidylcholine transfer proteinPC-TP; START domain-containing protein 2; StARD2; StAR-related lipid transfer protein 2Homo sapiens (human)
Phospholipase A2, membrane associatedEC 3.1.1.4; GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2AHomo sapiens (human)
Choline kinase alphaCK; EC 2.7.1.32; CHETK-alpha; Ethanolamine kinase; EK; 2.7.1.82Homo sapiens (human)
Cytosolic phospholipase A2cPLA2; Phospholipase A2 group IVAHomo sapiens (human)
Phosphoethanolamine/phosphocholine phosphataseEC 3.1.3.75Homo sapiens (human)
StAR-related lipid transfer protein 7, mitochondrialGestational trophoblastic tumor protein 1; START domain-containing protein 7; StARD7Homo sapiens (human)
Choline O-acetyltransferaseCHOACTase; ChAT; Choline acetylase; EC 2.3.1.6Homo sapiens (human)
Lysophosphatidylcholine acyltransferase 1LPC acyltransferase 1; LPCAT-1; LysoPC acyltransferase 1; EC 2.3.1.23; 1-acylglycerol-3-phosphate O-acyltransferase; 2.3.1.51; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 2.3.1.25; 1-alkylglycerophosphoHomo sapiens (human)
Choline-phosphate cytidylyltransferase AEC 2.7.7.15; CCT-alpha; CTP:phosphocholine cytidylyltransferase A; CCT A; CT A; Phosphorylcholine transferase AHomo sapiens (human)
Secretory phospholipase A2 receptorPLA2-R; PLA2R; 180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptorHomo sapiens (human)
Glycerol-3-phosphate dehydrogenase, mitochondrialGPD-M; GPDH-M; EC 1.1.5.3; mitohondrial glycerophosphate dehydrogenase gene; mGDH; mtGPDHomo sapiens (human)
Cardiolipin synthase (CMP-forming)CLS; EC 2.7.8.41; Protein GCD10 homologHomo sapiens (human)
Phospholipase B1, membrane-associatedPhospholipase B; hPLB; Lysophospholipase; 3.1.1.5; Phospholipase A2; 3.1.1.4; Phospholipase B/lipase; PLB/LIP; Triacylglycerol lipase; 3.1.1.3Homo sapiens (human)
Phosphatidylethanolamine N-methyltransferasePEAMT; PEMT; EC 2.1.1.17; EC 2.1.1.71; PEMT2; Phospholipid methyltransferase; PLMTHomo sapiens (human)
Ethanolamine-phosphate cytidylyltransferaseEC 2.7.7.14; CTP:phosphoethanolamine cytidylyltransferase; Phosphorylethanolamine transferaseHomo sapiens (human)
Lysophospholipid acyltransferase 7LPLAT 7; EC 2.3.1.-; 1-acylglycerophosphatidylinositol O-acyltransferase; Bladder and breast carcinoma-overexpressed gene 1 protein; Leukocyte receptor cluster member 4; Lysophosphatidylinositol acyltransferase; LPIAT; Lyso-PI acyltransferase; Membrane-boHomo sapiens (human)
Cholinephosphotransferase 1hCPT1; EC 2.7.8.2; AAPT1-like protein; Diacylglycerol cholinephosphotransferase 1Homo sapiens (human)
Ethanolaminephosphotransferase 1hEPT1; EC 2.7.8.1; Selenoprotein I; SelIHomo sapiens (human)
Ethanolamine-phosphate phospho-lyaseEC 4.2.3.2; Alanine--glyoxylate aminotransferase 2-like 1Homo sapiens (human)
Phosphatidylserine synthase 1PSS-1; PtdSer synthase 1; EC 2.7.8.29; Serine-exchange enzyme IHomo sapiens (human)
Phosphatidylserine synthase 2PSS-2; PtdSer synthase 2; EC 2.7.8.29; Serine-exchange enzyme IIHomo sapiens (human)
LysoplasmalogenaseEC 3.3.2.2; Transmembrane protein 86BHomo sapiens (human)
CDP-diacylglycerol--inositol 3-phosphatidyltransferaseEC 2.7.8.11; Phosphatidylinositol synthase; PI synthase; PtdIns synthaseHomo sapiens (human)
Phospholipase DDHD2EC 3.1.1.-; DDHD domain-containing protein 2; KIAA0725p; SAM, WWE and DDHD domain-containing protein 1Homo sapiens (human)
Phosphatidate cytidylyltransferase 2EC 2.7.7.41; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDS 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2Homo sapiens (human)
Phosphatidylinositol transfer protein beta isoformPI-TP-beta; PtdIns transfer protein beta; PtdInsTP betaHomo sapiens (human)
Phosphatidate phosphatase LPIN1EC 3.1.3.4; Lipin-1Homo sapiens (human)
TafazzinProtein G4.5Homo sapiens (human)
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialEC 2.7.8.5; Phosphatidylglycerophosphate synthase 1; PGP synthase 1Homo sapiens (human)
Phospholipase A1 member AEC 3.1.1.-; Phosphatidylserine-specific phospholipase A1; PS-PLA1Homo sapiens (human)
Diacylglycerol O-acyltransferase 2-like protein 6EC 2.3.1.-; Diacylglycerol O-acyltransferase candidate 3; hDC3Homo sapiens (human)
Mitoguardin 2Protein FAM73BHomo sapiens (human)
Mitochondrial cardiolipin hydrolaseEC 3.1.-.-; Choline phosphatase 6; Mitochondrial phospholipase; MitoPLD; Phosphatidylcholine-hydrolyzing phospholipase D6; Phospholipase D6; PLD 6; Protein zucchini homologHomo sapiens (human)
Sodium-dependent lysophosphatidylcholine symporter 1NLS1; Sodium-dependent LPC symporter 1; Major facilitator superfamily domain-containing protein 2AHomo sapiens (human)
Mitoguardin 1Protein FAM73AHomo sapiens (human)
Phospholipase DDHD1EC 3.1.1.-; DDHD domain-containing protein 1; Phosphatidic acid-preferring phospholipase A1 homolog; PA-PLA1Homo sapiens (human)
(Lyso)-N-acylphosphatidylethanolamine lipaseEC 3.1.1.-; Alpha/beta hydrolase domain-containing protein 4; Abhydrolase domain-containing protein 4; Alpha/beta-hydrolase 4Homo sapiens (human)
Phospholipase ABHD3EC 3.1.1.32; EC 3.1.1.4; Abhydrolase domain-containing protein 3Homo sapiens (human)
Phosphatidate phosphatase LPIN2EC 3.1.3.4; Lipin-2Homo sapiens (human)
Phosphatidate cytidylyltransferase 1EC 2.7.7.41; CDP-DAG synthase 1; CDP-DG synthase 1; CDP-diacylglycerol synthase 1; CDS 1; CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CTP:phosphatidate cytidylyltransferase 1Homo sapiens (human)
Phosphatidate phosphatase LPIN3EC 3.1.3.4; Lipin-3; Lipin-3-likeHomo sapiens (human)
Glycerophosphocholine phosphodiesterase GPCPD1EC 3.1.4.2; Glycerophosphodiester phosphodiesterase 5Homo sapiens (human)
Lysophosphatidic acid phosphatase type 6EC 3.1.3.2; Acid phosphatase 6, lysophosphatidic; Acid phosphatase-like protein 1; PACPL1Homo sapiens (human)
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilonEC 2.3.1.51; 1-acylglycerol-3-phosphate O-acyltransferase 5; 1-AGP acyltransferase 5; 1-AGPAT 5; Lysophosphatidic acid acyltransferase epsilon; LPAAT-epsilonHomo sapiens (human)
Phosphatidylserine decarboxylase proenzyme, mitochondrialEC 4.1.1.65Homo sapiens (human)
Choline-phosphate cytidylyltransferase BEC 2.7.7.15; CCT-beta; CTP:phosphocholine cytidylyltransferase B; CCT B; CT B; Phosphorylcholine transferase BHomo sapiens (human)

Compounds (33)

CompoundDescription
hydronium ion
cytidine diphosphate cholineDonor of choline in biosynthesis of choline-containing phosphoglycerides.
AcetylcholineA neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
NADH
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
cholineA basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
glycerolA trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
inositolAn isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
1,5-dihydro-FADchromophore component of E coli DNA photolyase
phosphorylethanolamineRN given refers to parent cpd; structure
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
acetaldehydeA colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
ethanolamineA viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.
alpha-glycerophosphoric acid
Cytidine MonophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Cytidine TriphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
paeonolstructure
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
CDP ethanolamine
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
glycerylphosphorylcholineA component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (From Stedman, 26th ed)
1-monomyristinisolated from the berries of SERENOA REPENS; structure in first source
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