Pathways > Glutathione synthesis and recycling
Page last updated: 2024-10-06
Glutathione synthesis and recycling
Proteins (11)
| Protein | Synonyms | Taxonomy |
|---|
| Glutamate--cysteine ligase regulatory subunit | GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit | Homo sapiens (human) |
| Glutathione hydrolase 1 proenzyme | EC 3.4.19.13; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; GGT 1; 2.3.2.2; Leukotriene-C4 hydrolase; 3.4.19.14 | Homo sapiens (human) |
| Glutamate--cysteine ligase catalytic subunit | EC 6.3.2.2; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase | Homo sapiens (human) |
| Glutathione synthetase | GSH synthetase; GSH-S; EC 6.3.2.3; Glutathione synthase | Homo sapiens (human) |
| Gamma-glutamylcyclotransferase | EC 4.3.2.9; Cytochrome c-releasing factor 21 | Homo sapiens (human) |
| Cytosolic non-specific dipeptidase | EC 3.4.13.18; CNDP dipeptidase 2; Carnosine dipeptidase II; Epididymis secretory protein Li 13; Glutamate carboxypeptidase-like protein 1; Peptidase A | Homo sapiens (human) |
| Putative glutathione hydrolase 3 proenzyme | EC 3.4.19.13; Gamma-glutamyltransferase 3; Putative gamma-glutamyltranspeptidase 3; GGT 3; 2.3.2.2 | Homo sapiens (human) |
| 5-oxoprolinase | EC 3.5.2.9; 5-oxo-L-prolinase; 5-OPase; Pyroglutamase | Homo sapiens (human) |
| Glutathione hydrolase 5 proenzyme | EC 3.4.19.13; Gamma-glutamyl transpeptidase-related enzyme; GGT-rel; Gamma-glutamyltransferase 5; GGT 5; 2.3.2.2; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase; 3.4.19.14 | Homo sapiens (human) |
| Glutathione hydrolase 6 | EC 3.4.19.13; Gamma-glutamyltransferase 6; GGT 6; 2.3.2.2; Gamma-glutamyltranspeptidase 6 | Homo sapiens (human) |
| Glutathione hydrolase 7 | EC 3.4.19.13; Gamma-glutamyltransferase 7; GGT 7; 2.3.2.2; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7 | Homo sapiens (human) |
Compounds (9)
| Compound | Description |
|---|
| Glutathione | A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. |
| Manganese | A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035) |
| Orthophosphate | |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| glutamate | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| Cysteine | A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. |