Pathways > Gemcitabine Metabolism Pathway
Page last updated: 2024-10-06
Gemcitabine Metabolism Pathway
Proteins (13)
| Protein | Synonyms | Taxonomy |
|---|
| Sodium/nucleoside cotransporter 1 | Concentrative nucleoside transporter 1; CNT 1; hCNT1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 | Homo sapiens (human) |
| Thymidylate synthase | TS; TSase; EC 2.1.1.45 | Homo sapiens (human) |
| Equilibrative nucleoside transporter 1 | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1 | Homo sapiens (human) |
| Nucleoside diphosphate kinase A | NDK A; NDP kinase A; EC 2.7.4.6; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated protein | Homo sapiens (human) |
| Ribonucleoside-diphosphate reductase large subunit | EC 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit | Homo sapiens (human) |
| Deoxycytidine kinase | dCK; EC 2.7.1.74; Deoxyadenosine kinase; 2.7.1.76; Deoxyguanosine kinase; 2.7.1.113 | Homo sapiens (human) |
| UMP-CMP kinase | EC 2.7.4.14; Deoxycytidylate kinase; CK; dCMP kinase; Nucleoside-diphosphate kinase; 2.7.4.6; Uridine monophosphate/cytidine monophosphate kinase; UMP/CMP kinase; UMP/CMPK | Homo sapiens (human) |
| Ribonucleoside-diphosphate reductase subunit M2 | EC 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit | Homo sapiens (human) |
| Deoxycytidylate deaminase | EC 3.5.4.12; dCMP deaminase | Homo sapiens (human) |
| Ribonucleoside-diphosphate reductase subunit M2 B | EC 1.17.4.1; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2 | Homo sapiens (human) |
| 5'(3')-deoxyribonucleotidase, cytosolic type | EC 3.1.3.-; Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1 | Homo sapiens (human) |
| Solute carrier family 28 member 3 | Concentrative Na(+)-nucleoside cotransporter 3; CNT 3; hCNT3 | Homo sapiens (human) |
| CTP synthase 1 | EC 6.3.4.2; CTP synthetase 1; UTP--ammonia ligase 1 | Homo sapiens (human) |
Compounds (8)
| Compound | Description |
|---|
| 2',2'-difluorodeoxycytidine 5'-triphosphate | |
| ammonium hydroxide | The hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution. |
| gemcitabine triphosphate | |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| gemcitabine | |
| gemcitabine-5'-diphosphate | structure in first source |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |