Page last updated: 2024-10-06

Gemcitabine Action Pathway

Proteins (13)

ProteinSynonymsTaxonomy
Sodium/nucleoside cotransporter 1Concentrative nucleoside transporter 1; CNT 1; hCNT1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1Homo sapiens (human)
Thymidylate synthaseTS; TSase; EC 2.1.1.45Homo sapiens (human)
Equilibrative nucleoside transporter 1Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1Homo sapiens (human)
Nucleoside diphosphate kinase ANDK A; NDP kinase A; EC 2.7.4.6; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated proteinHomo sapiens (human)
Ribonucleoside-diphosphate reductase large subunitEC 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunitHomo sapiens (human)
Deoxycytidine kinasedCK; EC 2.7.1.74; Deoxyadenosine kinase; 2.7.1.76; Deoxyguanosine kinase; 2.7.1.113Homo sapiens (human)
UMP-CMP kinase EC 2.7.4.14; Deoxycytidylate kinase; CK; dCMP kinase; Nucleoside-diphosphate kinase; 2.7.4.6; Uridine monophosphate/cytidine monophosphate kinase; UMP/CMP kinase; UMP/CMPKHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2EC 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunitHomo sapiens (human)
Deoxycytidylate deaminaseEC 3.5.4.12; dCMP deaminaseHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2 BEC 1.17.4.1; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2Homo sapiens (human)
5'(3')-deoxyribonucleotidase, cytosolic typeEC 3.1.3.-; Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1Homo sapiens (human)
Solute carrier family 28 member 3Concentrative Na(+)-nucleoside cotransporter 3; CNT 3; hCNT3Homo sapiens (human)
CTP synthase 1EC 6.3.4.2; CTP synthetase 1; UTP--ammonia ligase 1Homo sapiens (human)

Compounds (8)

CompoundDescription
2',2'-difluorodeoxycytidine 5'-triphosphate
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
gemcitabine triphosphate
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
gemcitabine
gemcitabine-5'-diphosphatestructure in first source
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)