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Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases

Proteins (6)

ProteinSynonymsTaxonomy
Dipeptidase 1EC 3.4.13.19; Beta-lactamase; 3.5.2.6; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDPHomo sapiens (human)
Glutathione hydrolase 1 proenzymeEC 3.4.19.13; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; GGT 1; 2.3.2.2; Leukotriene-C4 hydrolase; 3.4.19.14Homo sapiens (human)
Glutamate--cysteine ligase catalytic subunitEC 6.3.2.2; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetaseHomo sapiens (human)
Glutathione synthetaseGSH synthetase; GSH-S; EC 6.3.2.3; Glutathione synthaseHomo sapiens (human)
Gamma-glutamylcyclotransferaseEC 4.3.2.9; Cytochrome c-releasing factor 21Homo sapiens (human)
5-oxoprolinaseEC 3.5.2.9; 5-oxo-L-prolinase; 5-OPase; PyroglutamaseHomo sapiens (human)

Compounds (8)

CompoundDescription
GlutathioneA tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
glycineA non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
gamma-glutamylcysteine
Glutamate
pyrrolidonecarboxylic acidA cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
cysteinylglycineRN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83