Page last updated: 2024-10-06

Galactose Degradation/Leloir Pathway

Proteins (13)

ProteinSynonymsTaxonomy
Beta-galactosidaseBeta-gal; EC 3.2.1.23; LactaseEscherichia coli K-12
Lactose permeaseLactose-proton symportEscherichia coli K-12
Galactose-1-phosphate uridylyltransferaseGal-1-P uridylyltransferase; EC 2.7.7.12; UDP-glucose--hexose-1-phosphate uridylyltransferaseEscherichia coli K-12
GalactokinaseEC 2.7.1.6; Galactose kinaseEscherichia coli K-12
Aldose 1-epimeraseEC 5.1.3.3; Galactose mutarotase; Type-1 mutarotaseEscherichia coli K-12
Phosphocarrier protein HPrHistidine-containing proteinEscherichia coli K-12
Phosphoglucomutase-1PGM 1; EC 5.4.2.2; Glucose phosphomutase 1Homo sapiens (human)
UDP-glucose 4-epimeraseEC 5.1.3.2; Galactowaldenase; UDP-galactose 4-epimeraseEscherichia coli K-12
Galactose-proton symporterGalactose transporterEscherichia coli K-12
UTP--glucose-1-phosphate uridylyltransferaseEC 2.7.7.9; Alpha-D-glucosyl-1-phosphate uridylyltransferase; UDP-glucose pyrophosphorylase; UDPGP; Uridine diphosphoglucose pyrophosphorylaseEscherichia coli K-12
PTS system glucose-specific EIIA componentEIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA componentEscherichia coli K-12
PTS system glucose-specific EIICB componentEIICB-Glc; EII-GlcEscherichia coli K-12
Beta-phosphoglucomutaseBeta-PGM; EC 5.4.2.6Escherichia coli K-12

Compounds (14)

CompoundDescription
hydronium ion
galactoseAn aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
galactoseAn aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
uridine triphosphateUridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
glucose, (beta-d)-isomer
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
galactose-1-phosphate
uridine diphosphate galactoseA nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. Serves as a source of galactose in the synthesis of lipopolysaccharides, cerebrosides, and lactose.
glucose-1-phosphateRN given refers to (alpha-D-Glc)-isomer
Glucose-6-PhosphateAn ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
pyrophosphate
glucoseA primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.