Page last updated: 2024-10-06

GABA synthesis, release, reuptake and degradation

Proteins (15)

ProteinSynonymsTaxonomy
Glutamate decarboxylase 1EC 4.1.1.15; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoformHomo sapiens (human)
Sodium- and chloride-dependent betaine transporterBGT-1; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12Homo sapiens (human)
4-aminobutyrate aminotransferase, mitochondrialEC 2.6.1.19; (S)-3-amino-2-methylpropionate transaminase; 2.6.1.22; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBATHomo sapiens (human)
Heat shock cognate 71 kDa proteinEC 3.6.4.10; Heat shock 70 kDa protein 8; Lipopolysaccharide-associated protein 1; LAP-1; LPS-associated protein 1Homo sapiens (human)
Glutamate decarboxylase 2EC 4.1.1.15; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoformHomo sapiens (human)
DnaJ homolog subfamily C member 5Ceroid-lipofuscinosis neuronal protein 4; Cysteine string protein; CSPHomo sapiens (human)
Succinate-semialdehyde dehydrogenase, mitochondrialEC 1.2.1.24; Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenaseHomo sapiens (human)
Vesicular inhibitory amino acid transporterGABA and glycine transporter; Solute carrier family 32 member 1; Vesicular GABA transporter; hVIAATHomo sapiens (human)
Synaptosomal-associated protein 25SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa proteinHomo sapiens (human)
Synaptotagmin-1Synaptotagmin I; SytI; p65Homo sapiens (human)
Vesicle-associated membrane protein 2VAMP-2; Synaptobrevin-2Homo sapiens (human)
Regulating synaptic membrane exocytosis protein 1Rab-3-interacting molecule 1; RIM 1; Rab-3-interacting protein 2Homo sapiens (human)
Complexin-1Complexin I; CPX I; Synaphin-2Homo sapiens (human)
Ras-related protein Rab-3AHomo sapiens (human)
Syntaxin-1ANeuron-specific antigen HPC-1Homo sapiens (human)

Compounds (11)

CompoundDescription
hydronium ion
Succinate
NADH
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
chlorineAn element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
alpha-Ketoglutarate
glutamate