Page last updated: 2024-10-06

GABA metabolism (aka GHB)

Proteins (11)

ProteinSynonymsTaxonomy
Glutaminase liver isoform, mitochondrialGLS; EC 3.5.1.2; L-glutaminase; L-glutamine amidohydrolaseHomo sapiens (human)
Glutamate decarboxylase 1EC 4.1.1.15; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoformHomo sapiens (human)
Amine oxidase [flavin-containing] BEC 1.4.3.4; Monoamine oxidase type B; MAO-BHomo sapiens (human)
4-aminobutyrate aminotransferase, mitochondrialEC 2.6.1.19; (S)-3-amino-2-methylpropionate transaminase; 2.6.1.22; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBATHomo sapiens (human)
Serum paraoxonase/lactonase 3EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1Homo sapiens (human)
Dipeptidase 1EC 3.4.13.19; Beta-lactamase; 3.5.2.6; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDPHomo sapiens (human)
Hydroxyacid-oxoacid transhydrogenase, mitochondrialHOT; EC 1.1.99.24; Alcohol dehydrogenase iron-containing protein 1; ADHFe1; Fe-containing alcohol dehydrogenaseHomo sapiens (human)
Glutamate decarboxylase 2EC 4.1.1.15; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoformHomo sapiens (human)
Glutaminase kidney isoform, mitochondrialGLS; EC 3.5.1.2; K-glutaminase; L-glutamine amidohydrolaseHomo sapiens (human)
Succinate-semialdehyde dehydrogenase, mitochondrialEC 1.2.1.24; Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenaseHomo sapiens (human)
Aflatoxin B1 aldehyde reductase member 2EC 1.1.1.n11; AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductaseHomo sapiens (human)

Compounds (20)

CompoundDescription
4-hydroxybutyric acidwas an entry term to Sodium Oxybate (74-98)
pyridoxal phosphateThis is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Succinate
4-hydroxybutyric acidwas an entry term to Sodium Oxybate (74-98)
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
GlutamineA non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
glycolic acidRN given refers to parent cpd
4-hydroxybutanalmetabolite of 5-fluorouracil; structure in first source
homocarnosineRN given refers to parent cpd
uracilOne of four nucleotide bases in the nucleic acid RNA.
alpha-Ketoglutarate
beta-alanineAn amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.
D-2-hydroxyglutarate
hydracrylic acid
4-butyrolactoneOne of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
malonic semialdehydeRN given refers to parent cpd; structure given in first source
putrescineA toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
n-acetylputrescine
3,4-dihydroxybutanoic acidendogenous sugar acid from serum of fasted rates acting as satiety factor in rats; RN given refers to parent cpd
1,4-butanediol