Pathways > G alpha (i) signalling events
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G alpha (i) signalling events

Proteins (86)

ProteinSynonymsTaxonomy
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PP-1A; EC 3.1.3.16Homo sapiens (human)
Kininogen-1 Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK; Williams-Fitzgerald-Flaujeac factorHomo sapiens (human)
PrepronociceptinHomo sapiens (human)
Proto-oncogene tyrosine-protein kinase SrcEC 2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-SrcHomo sapiens (human)
fMet-Leu-Phe receptorfMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptorHomo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
C-C chemokine receptor type 7C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptorHomo sapiens (human)
C-X-C chemokine receptor type 5CXC-R5; CXCR-5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15Homo sapiens (human)
Mu-type opioid receptorM-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOPHomo sapiens (human)
C-C chemokine receptor type 6C-C CKR-6; CC-CKR-6; CCR-6; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptorHomo sapiens (human)
Cyclin-dependent-like kinase 5 EC 2.7.11.1; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunitHomo sapiens (human)
Calcium/calmodulin-dependent protein kinase type II subunit gammaCaM kinase II subunit gamma; CaMK-II subunit gamma; EC 2.7.11.17Homo sapiens (human)
Histamine H4 receptorH4R; HH4R; AXOR35; G-protein coupled receptor 105; GPRv53; Pfi-013; SP9144Homo sapiens (human)
Relaxin-3 receptor 1RLN3 receptor 1; G protein-coupled receptor SALPR; G-protein coupled receptor GPCR135; Relaxin family peptide receptor 3; Somatostatin- and angiotensin-like peptide receptorHomo sapiens (human)
Calcineurin subunit B type 1Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1Homo sapiens (human)
Prosaposin receptor GPR37Endothelin B receptor-like protein 1; ETBR-LP-1; G-protein coupled receptor 37; Parkin-associated endothelin receptor-like receptor; PAELRHomo sapiens (human)
cAMP-dependent protein kinase catalytic subunit alphaPKA C-alpha; EC 2.7.11.11Homo sapiens (human)
C-X-C chemokine receptor type 1CXC-R1; CXCR-1; CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1Homo sapiens (human)
C-X-C chemokine receptor type 2CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2Homo sapiens (human)
Nociceptin receptorKappa-type 3 opioid receptor; KOR-3; Orphanin FQ receptorHomo sapiens (human)
Extracellular calcium-sensing receptorCaR; CaSR; hCasR; Parathyroid cell calcium-sensing receptor 1; PCaR1Homo sapiens (human)
Prostaglandin E2 receptor EP3 subtypePGE receptor EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; Prostanoid EP3 receptorHomo sapiens (human)
Hydroxycarboxylic acid receptor 3G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; Niacin receptor 2; Nicotinic acid receptor 2Homo sapiens (human)
C-X-C chemokine receptor type 3CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptorHomo sapiens (human)
Type-2 angiotensin II receptorAngiotensin II type-2 receptor; AT2Homo sapiens (human)
C-C chemokine receptor type 8C-C CKR-8; CC-CKR-8; CCR-8; CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1Homo sapiens (human)
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1ACam-PDE 1A; EC 3.1.4.17; 61 kDa Cam-PDE; hCam-1Homo sapiens (human)
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BCam-PDE 1B; EC 3.1.4.17; 63 kDa Cam-PDEHomo sapiens (human)
Calcium/calmodulin-dependent protein kinase type IVCaMK IV; EC 2.7.11.17; CaM kinase-GRHomo sapiens (human)
Hydroxycarboxylic acid receptor 2G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptorHomo sapiens (human)
P2Y purinoceptor 12P2Y12; ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999Homo sapiens (human)
Prostaglandin D2 receptor 2Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44Homo sapiens (human)
cAMP-dependent protein kinase type II-alpha regulatory subunitHomo sapiens (human)
S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; AdoHcyase 2Homo sapiens (human)
AngiotensinogenSerpin A8Homo sapiens (human)
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor12-(S)-HETE receptor; 12-HETER; G-protein coupled receptor 31; GPR31/12-HETERHomo sapiens (human)
C-C motif chemokine 5EoCP; Eosinophil chemotactic cytokine; SIS-delta; Small-inducible cytokine A5; T cell-specific protein P228; TCP228; T-cell-specific protein RANTESHomo sapiens (human)
Cyclic AMP-responsive element-binding protein 1CREB-1; cAMP-responsive element-binding protein 1Homo sapiens (human)
P2Y purinoceptor 4P2Y4; P2P; Uridine nucleotide receptor; UNRHomo sapiens (human)
P2Y purinoceptor 14P2Y14; G-protein coupled receptor 105; UDP-glucose receptorHomo sapiens (human)
P2Y purinoceptor 13P2Y13; G-protein coupled receptor 86; G-protein coupled receptor 94Homo sapiens (human)
2-oxoglutarate receptor 1Alpha-ketoglutarate receptor 1; G-protein coupled receptor 80; G-protein coupled receptor 99; P2Y purinoceptor 15; P2Y15; P2Y-like GPCR; P2Y-like nucleotide receptorHomo sapiens (human)
Succinate receptor 1G-protein coupled receptor 91; P2Y purinoceptor 1-likeHomo sapiens (human)
Complement C5C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4Homo sapiens (human)
C-X-C chemokine receptor type 6CXC-R6; CXCR-6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzoHomo sapiens (human)
Calmodulin-1Homo sapiens (human)
C5a anaphylatoxin chemotactic receptor 1C5a anaphylatoxin chemotactic receptor; C5a-R; C5aRHomo sapiens (human)
N-formyl peptide receptor 2FMLP-related receptor I; FMLP-R-I; Formyl peptide receptor-like 1; HM63; Lipoxin A4 receptor; LXA4 receptor; RFPHomo sapiens (human)
Beta-adrenergic receptor kinase 1Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2Homo sapiens (human)
C-C chemokine receptor type 10C-C CKR-10; CC-CKR-10; CCR-10; G-protein coupled receptor 2Homo sapiens (human)
Cytosolic phospholipase A2cPLA2; Phospholipase A2 group IVAHomo sapiens (human)
CX3C chemokine receptor 1C-X3-C CKR-1; CX3CR1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28Homo sapiens (human)
C-C chemokine receptor type 9C-C CKR-9; CC-CKR-9; CCR-9; G-protein coupled receptor 28; GPR-9-6Homo sapiens (human)
Calcium/calmodulin-dependent protein kinase type II subunit betaCaM kinase II subunit beta; CaMK-II subunit beta; EC 2.7.11.17Homo sapiens (human)
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CCam-PDE 1C; 3',5'-cyclic-AMP phosphodiesterase; 3.1.4.-; 3',5'-cyclic-GMP phosphodiesterase; 3.1.4.35; Hcam3Homo sapiens (human)
N-arachidonyl glycine receptorNAGly receptor; G-protein coupled receptor 18Homo sapiens (human)
C3a anaphylatoxin chemotactic receptorC3AR; C3a-RHomo sapiens (human)
Oxoeicosanoid receptor 15-oxo-ETE G-protein coupled receptor; G-protein coupled receptor 170; G-protein coupled receptor R527; G-protein coupled receptor TG1019Homo sapiens (human)
G-protein coupled estrogen receptor 1Chemoattractant receptor-like 2; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; G protein-coupled estrogen receptor 1; G-protein coupled receptor 30; GPCR-Br; IL8-related receptor DRY12; Lymphocyte-derived G-protein coupled receptor; LYGPR;Homo sapiens (human)
Hydroxycarboxylic acid receptor 1G-protein coupled receptor 104; G-protein coupled receptor 81Homo sapiens (human)
Complement C3C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1Homo sapiens (human)
Stromal cell-derived factor 1SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSFHomo sapiens (human)
G-protein coupled receptor 183Epstein-Barr virus-induced G-protein coupled receptor 2; EBI2; EBV-induced G-protein coupled receptor 2; hEBI2Homo sapiens (human)
Apelin receptorAngiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11Homo sapiens (human)
Uracil nucleotide/cysteinyl leukotriene receptorUDP/CysLT receptor; G-protein coupled receptor 17; P2Y-like receptor; R12Homo sapiens (human)
Relaxin-3 receptor 2RLN3 receptor 2; G-protein coupled receptor 100; G-protein coupled receptor GPCR142; Insulin-like peptide INSL5 receptor; Relaxin family peptide receptor 4Homo sapiens (human)
C-C motif chemokine 25Chemokine TECK; Small-inducible cytokine A25; Thymus-expressed chemokineHomo sapiens (human)
G-protein coupled receptor 37-like 1Endothelin B receptor-like protein 2; ETBR-LP-2Homo sapiens (human)
Neuromedin-U receptor 2NMU-R2; G-protein coupled receptor FM-4; G-protein coupled receptor TGR-1Homo sapiens (human)
Importin subunit alpha-1Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alphaHomo sapiens (human)
C-X-C motif chemokine 13Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13Homo sapiens (human)
C-C motif chemokine 20Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20Homo sapiens (human)
FractalkineC-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1Homo sapiens (human)
Galanin peptidesHomo sapiens (human)
C-C motif chemokine 16Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16Homo sapiens (human)
Guanine nucleotide-binding protein G(z) subunit alphaG(x) alpha chain; Gz-alphaHomo sapiens (human)
Pro-MCHHomo sapiens (human)
C-C motif chemokine 1Small-inducible cytokine A1; T lymphocyte-secreted protein I-309Homo sapiens (human)
N-formyl peptide receptor 3FMLP-related receptor II; FMLP-R-II; Formyl peptide receptor-like 2Homo sapiens (human)
Guanine nucleotide-binding protein G(olf) subunit alphaAdenylate cyclase-stimulating G alpha protein, olfactory typeHomo sapiens (human)
Neuromedin-UHomo sapiens (human)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoformPP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-deltaHomo sapiens (human)
Neuromedin-SHomo sapiens (human)
NeurobeachinLysosomal-trafficking regulator 2; Protein BCL8BHomo sapiens (human)
C-C motif chemokine 13CK-beta-10; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; MCP-4; NCC-1; Small-inducible cytokine A13Homo sapiens (human)
C-X-C motif chemokine 16Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SR-PSOX; Small-inducible cytokine B16; Transmembrane chemokine CXCL16Homo sapiens (human)

Compounds (35)

CompoundDescription
l-lactic acid
Succinate
AcetylcholineA neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
IronA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
Dopamine Hydrochloride
dinoprostoneThe most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Uridine TriphosphateUridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
melatoninA biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
7,25-dihydroxycholesterolhas various immunosupressive effects; RN given refers to (3beta)-isomer; RN for cpd without isomeric designation not available 12/88
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
alpha-Ketoglutarate
SerotoninA biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
12-hydroxy-5,8,10,14-eicosatetraenoic acidA lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
5-oxo-6,8,11,14-eicosatetraenoic acidRN given is for cpd without isomeric designation; an arachidonate metabolite which stimulates neutrophils to mobilize Ca and promotes PMN degranulation responses
n-arachidonylglycinestructure in first source
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
cyclic ampAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Peremin
n-formylmethionine leucyl-phenylalanineA formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.
prostaglandin d2The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
sphingosine 1-phosphateRN given refers to (R-(R*,S*-(E)))-isomer; RN for cpd without isomeric designation not available 8/89