Page last updated: 2024-10-06
Fluoropyrimidine activity
Proteins (0)
Compounds (13)
| Compound | Description |
|---|---|
| leucovorin | The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS. |
| fluorouracil | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid. |
| capecitabine | A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER. |
| dihydrofolate | RN given refers to (L)-isomer |
| 5-fluorouridine 5'-triphosphate | |
| 5-formyl-2'-deoxyuridine 5'-triphosphate | |
| 5'-deoxy-5-fluorocytidine | structure in first source |
| 5-fluorodihydrouracil | metabolite of 5-fluorouracil; RN given refers to parent cpd |
| alpha-fluoro-beta-alanine | metabolite of HCFU & 5-fluorouracil; structure in first source |
| thymidine monophosphate | 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety. |
| alpha-fluoro-beta-ureidopropionic acid | fluorouracil metabolite; structure given in first source |
| 2'-deoxyuridylic acid | RN given refers to parent cpd |
| fluorodeoxyuridylate | 5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine. |