Page last updated: 2024-10-06

Fluoropyrimidine Pathway, Pharmacokinetics

Proteins (24)

ProteinSynonymsTaxonomy
ATP-binding cassette sub-family C member 3EC 7.6.2.-; EC 7.6.2.2; EC 7.6.2.3; Canalicular multispecific organic anion transporter 2; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3Homo sapiens (human)
Multidrug resistance-associated protein 5ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11Homo sapiens (human)
Broad substrate specificity ATP-binding cassette transporter ABCG2EC 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporterHomo sapiens (human)
Uridine-cytidine kinase 2UCK 2; EC 2.7.1.48; Cytidine monophosphokinase 2; Testis-specific protein TSA903; Uridine monophosphokinase 2Homo sapiens (human)
Multidrug resistance-associated protein 4ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-BHomo sapiens (human)
Thymidylate synthaseTS; TSase; EC 2.1.1.45Homo sapiens (human)
Cytochrome P450 2A6EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I)Homo sapiens (human)
Equilibrative nucleoside transporter 1Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1Homo sapiens (human)
Dihydropyrimidine dehydrogenase [NADP(+)]DHPDHase; DPD; EC 1.3.1.2; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenaseHomo sapiens (human)
Liver carboxylesterase 1Acyl-coenzyme A:cholesterol acyltransferase; ACAT; Brain carboxylesterase hBr1; Carboxylesterase 1; CE-1; hCE-1; 3.1.1.1; Cholesteryl ester hydrolase; CEH; 3.1.1.13; Cocaine carboxylesterase; Egasyn; HMSE; Methylumbelliferyl-acetate deacetylase 1; 3.1.1.5Homo sapiens (human)
Ribonucleoside-diphosphate reductase large subunitEC 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunitHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2EC 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunitHomo sapiens (human)
Cocaine esteraseEC 3.1.1.84; Carboxylesterase 2; CE-2; hCE-2; 3.1.1.1; Methylumbelliferyl-acetate deacetylase 2; 3.1.1.56Homo sapiens (human)
Thymidine kinase, cytosolicEC 2.7.1.21Homo sapiens (human)
Solute carrier family 22 member 7Novel liver transporter; Organic anion transporter 2; hOAT2Homo sapiens (human)
Uridine phosphorylase 2UPase 2; UrdPase 2; EC 2.4.2.3Homo sapiens (human)
DihydropyrimidinaseDHP; DHPase; EC 3.5.2.2; Dihydropyrimidine amidohydrolase; HydantoinaseHomo sapiens (human)
Cytidine deaminaseEC 3.5.4.5; Cytidine aminohydrolaseHomo sapiens (human)
Uridine phosphorylase 1UPase 1; UrdPase 1; EC 2.4.2.3Homo sapiens (human)
OTTHUMP00000022401Homo sapiens (human)
Thymidine phosphorylase Homo sapiens (human)
cDNA FLJ14215 fis, clone NT2RP3003665, highly similar to Beta-ureidopropionaseHomo sapiens (human)
Amidophosphoribosyltransferase Homo sapiens (human)
OMPdecase Homo sapiens (human)

Compounds (5)

CompoundDescription
5-fluorouridine 5'-triphosphate
5-formyl-2'-deoxyuridine 5'-triphosphate
5'-deoxy-5-fluorocytidinestructure in first source
5-fluorodihydrouracilmetabolite of 5-fluorouracil; RN given refers to parent cpd
doxifluridine