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Female steroid hormones in cardiomyocyte energy metabolism

Proteins (6)

ProteinSynonymsTaxonomy
Estrogen receptorER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1Homo sapiens (human)
ATP-citrate synthaseEC 2.3.3.8; ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzymeHomo sapiens (human)
Peroxisome proliferator-activated receptor alphaPPAR-alpha; Nuclear receptor subfamily 1 group C member 1Homo sapiens (human)
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialMCAD; EC 1.3.8.7; Medium chain acyl-CoA dehydrogenase; MCADHHomo sapiens (human)
Steroid hormone receptor ERR1Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1Homo sapiens (human)
Peroxisome proliferator-activated receptor gamma coactivator 1-betaPGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; PGC-1-related estrogen receptor alpha coactivatorHomo sapiens (human)

Compounds (3)

CompoundDescription
tamoxifenOne of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
cyclic gmpGuanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Cyclic AMPAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.