Pathways > Factors involved in megakaryocyte development and platelet production
Page last updated: 2024-10-06

Factors involved in megakaryocyte development and platelet production

Proteins (50)

ProteinSynonymsTaxonomy
Transcriptional activator MybProto-oncogene c-MybHomo sapiens (human)
Probable JmjC domain-containing histone demethylation protein 2CEC 1.14.11.-; Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8Homo sapiens (human)
Kinesin-like protein KIF18AMarrow stromal KIF18A; MS-KIF18AHomo sapiens (human)
Lysine-specific histone demethylase 1AEC 1.14.99.66; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2; [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1AHomo sapiens (human)
Tyrosine-protein kinase JAK2EC 2.7.10.2; Janus kinase 2; JAK-2Homo sapiens (human)
Tyrosine-protein kinase ABL1EC 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Cyclin-dependent kinase 2EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinaseHomo sapiens (human)
Kinesin-like protein KIF11Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5Homo sapiens (human)
Cyclin-dependent-like kinase 5 EC 2.7.11.1; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunitHomo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
Histone deacetylase 2HD2; EC 3.5.1.98Homo sapiens (human)
Transcription factor NF-E2 45 kDa subunitLeucine zipper protein NF-E2; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2Homo sapiens (human)
Kinesin-like protein KIF2CKinesin-like protein 6; Mitotic centromere-associated kinesin; MCAKHomo sapiens (human)
F-actin-capping protein subunit betaCapZ betaHomo sapiens (human)
Kinesin-like protein KIF3AMicrotubule plus end-directed kinesin motor 3AHomo sapiens (human)
Inositol-tetrakisphosphate 1-kinaseEC 2.7.1.134; Inositol 1,3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase; 2.7.1.159Homo sapiens (human)
Kinesin-like protein KIF3BHH0048; Microtubule plus end-directed kinesin motor 3BHomo sapiens (human)
Hemoglobin subunit epsilonEpsilon-globin; Hemoglobin epsilon chainHomo sapiens (human)
Wee1-like protein kinaseWEE1hu; EC 2.7.10.2; Wee1A kinaseHomo sapiens (human)
Centromere-associated protein ECentromere protein E; CENP-E; Kinesin-7; Kinesin-related protein CENPEHomo sapiens (human)
Kinesin-like protein KIF9Homo sapiens (human)
Kinesin-like protein KIFC1Kinesin-like protein 2; Kinesin-related protein HSETHomo sapiens (human)
REST corepressor 1Protein CoRESTHomo sapiens (human)
Kinesin-like protein KIF2AKinesin-2; hK2Homo sapiens (human)
Hemoglobin subunit betaBeta-globin; Hemoglobin beta chainHomo sapiens (human)
Kinesin-like protein KIF15Kinesin-like protein 2; hKLP2; Kinesin-like protein 7; Serologically defined breast cancer antigen NY-BR-62Homo sapiens (human)
Chromobox protein homolog 5Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alphaHomo sapiens (human)
Hemoglobin subunit deltaDelta-globin; Hemoglobin delta chainHomo sapiens (human)
DNA repair protein RAD51 homolog 2R51H2; RAD51 homolog B; Rad51B; RAD51-like protein 1Homo sapiens (human)
Interferon regulatory factor 1IRF-1Homo sapiens (human)
Ras-related protein Rab-5AEC 3.6.5.2Homo sapiens (human)
Rac GTPase-activating protein 1Male germ cell RacGap; MgcRacGAP; Protein CYK4 homolog; CYK4; HsCYK-4Homo sapiens (human)
DNA repair protein RAD51 homolog 3R51H3; RAD51 homolog C; RAD51-like protein 2Homo sapiens (human)
Interferon regulatory factor 2IRF-2Homo sapiens (human)
Hemoglobin subunit gamma-1Gamma-1-globin; Hb F Agamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chainHomo sapiens (human)
Hemoglobin subunit gamma-2Gamma-2-globin; Hb F Ggamma; Hemoglobin gamma-2 chain; Hemoglobin gamma-G chainHomo sapiens (human)
F-actin-uncapping protein LRRC16ACARMIL homolog; Capping protein regulator and myosin 1 linker protein 1; Capping protein, Arp2/3 and myosin-I linker homolog 1; Capping protein, Arp2/3 and myosin-I linker protein 1; Leucine-rich repeat-containing protein 16AHomo sapiens (human)
Kinesin-like protein KIF2BHomo sapiens (human)
CDK5 and ABL1 enzyme substrate 1Interactor with CDK3 1; Ik3-1Homo sapiens (human)
[F-actin]-monooxygenase MICAL1EC 1.14.13.225; Molecule interacting with CasL protein 1; MICAL-1; NEDD9-interacting protein with calponin homology and LIM domainsHomo sapiens (human)
Kinesin-associated protein 3KAP-3; KAP3; Smg GDS-associated proteinHomo sapiens (human)
PHD finger protein 21ABHC80a; BRAF35-HDAC complex protein BHC80Homo sapiens (human)
Paired amphipathic helix protein Sin3aHistone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3aHomo sapiens (human)
Rabenosyn-5110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN; Zinc finger FYVE domain-containing protein 20Homo sapiens (human)
Vacuolar protein sorting-associated protein 45h-VPS45; hlVps45Homo sapiens (human)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-relatedSMARCE1-related protein; BRCA2-associated factor 35; HMG box-containing protein 20B; HMG domain-containing protein 2; HMG domain-containing protein HMGX2; Sox-like transcriptional factor; Structural DNA-binding protein BRAF35Homo sapiens (human)
GTP:AMP phosphotransferase AK3, mitochondrialEC 2.7.4.10; Adenylate kinase 3; AK 3; Adenylate kinase 3 alpha-like 1Homo sapiens (human)
Kinesin-like protein Homo sapiens (human)
Kinesin-like protein Homo sapiens (human)

Compounds (14)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
myo-inositol 1,3,4,5,6-pentakisphosphate
Nalidixic AcidA synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
inositol-1,3,4,6-tetrakisphosphatefor cpd without numerical locants of phosphate groups, index INOSITOL PHOSPHATES
inositol 1,3,4-trisphosphate
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)