Pathways > FOXO-mediated transcription
Page last updated: 2024-10-06

FOXO-mediated transcription

Proteins (60)

ProteinSynonymsTaxonomy
CatalaseEC 1.11.1.6Homo sapiens (human)
Ataxin-3EC 3.4.19.12; Machado-Joseph disease protein 1; Spinocerebellar ataxia type 3 proteinHomo sapiens (human)
ResistinAdipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3Homo sapiens (human)
Glucocorticoid receptorGR; Nuclear receptor subfamily 3 group C member 1Homo sapiens (human)
NAD-dependent protein deacetylase sirtuin-1hSIRT1; EC 2.3.1.286; NAD-dependent protein deacylase sirtuin-1; 2.3.1.-; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2Homo sapiens (human)
Tumor necrosis factor ligand superfamily member 6Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasLHomo sapiens (human)
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6Homo sapiens (human)
Hexokinase-4HK4; EC 2.7.1.1; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-DHomo sapiens (human)
Histone acetyltransferase p300p300 HAT; EC 2.3.1.48; E1A-associated protein p300; Histone butyryltransferase p300; 2.3.1.-; Histone crotonyltransferase p300; 2.3.1.-; Protein 2-hydroxyisobutyryltransferase p300; 2.3.1.-; Protein propionyltransferase p300; 2.3.1.-Homo sapiens (human)
NAD-dependent protein deacetylase sirtuin-3, mitochondrialhSIRT3; EC 2.3.1.286; Regulatory protein SIR2 homolog 3; SIR2-like protein 3Homo sapiens (human)
B-cell lymphoma 6 proteinBCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51Homo sapiens (human)
Cyclin-dependent kinase inhibitor 1BCyclin-dependent kinase inhibitor p27; p27Kip1Homo sapiens (human)
Caveolin-1Homo sapiens (human)
14-3-3 protein theta14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1Homo sapiens (human)
Forkhead box protein O3AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1Homo sapiens (human)
Glucose-6-phosphataseG-6-Pase; G6Pase; EC 3.1.3.9; Glucose-6-phosphatase alpha; G6Pase-alphaHomo sapiens (human)
Bcl-2-binding component 3, isoforms 1/2JFY-1; p53 up-regulated modulator of apoptosisHomo sapiens (human)
InsulinHomo sapiens (human)
14-3-3 protein sigmaEpithelial cell marker protein 1; StratifinHomo sapiens (human)
Serine/threonine-protein kinase PINK1, mitochondrialEC 2.7.11.1; BRPK; PTEN-induced putative kinase protein 1Homo sapiens (human)
Sterol regulatory element-binding protein 1SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1Homo sapiens (human)
Bcl-2-like protein 11Bcl2-L-11; Bcl2-interacting mediator of cell deathHomo sapiens (human)
ThioredoxinTrx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASPHomo sapiens (human)
Cyclin-dependent kinase inhibitor 1CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21Homo sapiens (human)
14-3-3 protein gammaProtein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
Mothers against decapentaplegic homolog 3MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3Homo sapiens (human)
Forkhead box protein O1Forkhead box protein O1A; Forkhead in rhabdomyosarcomaHomo sapiens (human)
Mothers against decapentaplegic homolog 2MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2Homo sapiens (human)
Serine/threonine-protein kinase STK11EC 2.7.11.1; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19Homo sapiens (human)
CREB-binding proteinHistone lysine acetyltransferase CREBBP; 2.3.1.48; Protein-lysine acetyltransferase CREBBP; 2.3.1.-Homo sapiens (human)
DNA damage-inducible transcript 3 proteinDDIT-3; C/EBP zeta; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA damage-inducible protein GADD153Homo sapiens (human)
Insulin-like growth factor-binding protein 1IBP-1; IGF-binding protein 1; IGFBP-1; Placental protein 12; PP12Homo sapiens (human)
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]PEPCK-C; EC 4.1.1.32; Serine-protein kinase PCK1; 2.7.11.-Homo sapiens (human)
14-3-3 protein beta/alphaProtein 1054; Protein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
Retinoblastoma-like protein 2130 kDa retinoblastoma-associated protein; p130; Retinoblastoma-related protein 2; RBR-2; pRb2Homo sapiens (human)
Mothers against decapentaplegic homolog 4MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4Homo sapiens (human)
Growth/differentiation factor 8GDF-8; MyostatinHomo sapiens (human)
14-3-3 protein zeta/deltaProtein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
F-box only protein 32Atrogin-1; Muscle atrophy F-box protein; MAFbxHomo sapiens (human)
Superoxide dismutase [Mn], mitochondrialEC 1.15.1.1Homo sapiens (human)
Forkhead box protein G1Brain factor 1; BF-1; BF1; Brain factor 2; BF-2; BF2; hBF-2; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; Forkhead-related protein FKHL1; HFK1; Forkhead-related protein FKHL2; HFK2; Forkhead-related protein FKHL3; HFK3Homo sapiens (human)
Agouti-related proteinHomo sapiens (human)
Pro-opiomelanocortinPOMC; Corticotropin-lipotropinHomo sapiens (human)
Cyclin-G2Homo sapiens (human)
Krueppel-like factor 4Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factorHomo sapiens (human)
Thioredoxin-interacting proteinThioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1Homo sapiens (human)
Forkhead box protein O6Homo sapiens (human)
Pro-neuropeptide YHomo sapiens (human)
Nuclear transcription factor Y subunit alphaCAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YAHomo sapiens (human)
Growth arrest and DNA damage-inducible protein GADD45 alphaDNA damage-inducible transcript 1 protein; DDIT-1Homo sapiens (human)
Nuclear transcription factor Y subunit betaCAAT box DNA-binding protein subunit B; Nuclear transcription factor Y subunit B; NF-YBHomo sapiens (human)
Poly(rC)-binding protein 4Alpha-CP4Homo sapiens (human)
Protein BTG1B-cell translocation gene 1 proteinHomo sapiens (human)
Forkhead box protein O4Fork head domain transcription factor AFX1Homo sapiens (human)
Nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C; NF-YC; Transactivator HSM-1/2Homo sapiens (human)
ATP-binding cassette sub-family A member 6Homo sapiens (human)
E3 ubiquitin-protein ligase TRIM63EC 2.3.2.27; Iris RING finger protein; Muscle-specific RING finger protein 1; MuRF-1; MuRF1; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; Striated muscle RING zinc finger protein; Tripartite motif-containing protein 63Homo sapiens (human)
Paired amphipathic helix protein Sin3aHistone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3aHomo sapiens (human)
Cbp/p300-interacting transactivator 2MSG-related protein 1; MRG-1; P35srjHomo sapiens (human)
Plexin-A4Homo sapiens (human)

Compounds (7)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
o-acetyl-adp-riboseAn acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
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