| Protein | Synonyms | Taxonomy |
|---|
| Transcription factor ETV6 | ETS translocation variant 6; ETS-related protein Tel1; Tel | Homo sapiens (human) |
| Serine/threonine-protein kinase pim-1 | EC 2.7.11.1 | Homo sapiens (human) |
| Receptor-type tyrosine-protein kinase FLT3 | EC 2.7.10.1; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1 | Homo sapiens (human) |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-k | Homo sapiens (human) |
| Tyrosine-protein phosphatase non-receptor type 11 | EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3 | Homo sapiens (human) |
| Bcl-2-like protein 1 | Bcl2-L-1; Apoptosis regulator Bcl-X | Homo sapiens (human) |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha | Homo sapiens (human) |
| Growth factor receptor-bound protein 2 | Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 | Homo sapiens (human) |
| Son of sevenless homolog 1 | SOS-1 | Homo sapiens (human) |
| Cyclin-dependent kinase inhibitor 1 | CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21 | Homo sapiens (human) |
| NADPH oxidase 4 | EC 1.6.3.-; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase | Homo sapiens (human) |
| Golgin subfamily B member 1 | 372 kDa Golgi complex-associated protein; GCP372; Giantin; Macrogolgin | Homo sapiens (human) |
| GRB2-associated-binding protein 2 | GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100 | Homo sapiens (human) |
| Fms-related tyrosine kinase 3 ligand | Flt3 ligand; Flt3L; SL cytokine | Homo sapiens (human) |
| Spectrin beta chain, non-erythrocytic 1 | Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1 | Homo sapiens (human) |
| Thyroid receptor-interacting protein 11 | TR-interacting protein 11; TRIP-11; Clonal evolution-related gene on chromosome 14 protein; Golgi-associated microtubule-binding protein 210; GMAP-210; Trip230 | Homo sapiens (human) |
| Unconventional myosin-XVIIIa | Molecule associated with JAK3 N-terminus; MAJN; Myosin containing a PDZ domain; Surfactant protein receptor SP-R210; SP-R210 | Homo sapiens (human) |
| Zinc finger MYM-type protein 2 | Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198 | Homo sapiens (human) |
| Compound | Description |
|---|
| hydronium ion | |
| sorafenib | A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy. |
| pexidartinib | inhibits both CSF1R and c-kit receptor tyrosine kinase; structure in first source |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| midostaurin | |
| Guanosine Monophosphate | A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. |
| Guanosine Diphosphate | A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. |
| kw 2449 | has both multikinase inhibitory activity and antineoplastic activity; structure in first source |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |