Pathways > FLT3 signaling in disease
Page last updated: 2024-10-06

FLT3 signaling in disease

Proteins (18)

ProteinSynonymsTaxonomy
Transcription factor ETV6ETS translocation variant 6; ETS-related protein Tel1; TelHomo sapiens (human)
Serine/threonine-protein kinase pim-1EC 2.7.11.1Homo sapiens (human)
Receptor-type tyrosine-protein kinase FLT3EC 2.7.10.1; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1Homo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 11EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3Homo sapiens (human)
Bcl-2-like protein 1Bcl2-L-1; Apoptosis regulator Bcl-XHomo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
Growth factor receptor-bound protein 2Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2Homo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
Cyclin-dependent kinase inhibitor 1CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21Homo sapiens (human)
NADPH oxidase 4EC 1.6.3.-; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidaseHomo sapiens (human)
Golgin subfamily B member 1372 kDa Golgi complex-associated protein; GCP372; Giantin; MacrogolginHomo sapiens (human)
GRB2-associated-binding protein 2GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100Homo sapiens (human)
Fms-related tyrosine kinase 3 ligandFlt3 ligand; Flt3L; SL cytokineHomo sapiens (human)
Spectrin beta chain, non-erythrocytic 1Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1Homo sapiens (human)
Thyroid receptor-interacting protein 11TR-interacting protein 11; TRIP-11; Clonal evolution-related gene on chromosome 14 protein; Golgi-associated microtubule-binding protein 210; GMAP-210; Trip230Homo sapiens (human)
Unconventional myosin-XVIIIaMolecule associated with JAK3 N-terminus; MAJN; Myosin containing a PDZ domain; Surfactant protein receptor SP-R210; SP-R210Homo sapiens (human)
Zinc finger MYM-type protein 2Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198Homo sapiens (human)

Compounds (13)

CompoundDescription
hydronium ion
sorafenibA niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.
pexidartinibinhibits both CSF1R and c-kit receptor tyrosine kinase; structure in first source
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
midostaurin
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
kw 2449has both multikinase inhibitory activity and antineoplastic activity; structure in first source
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
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