Page last updated: 2024-10-06

Epigenetic regulation of gene expression

Proteins (111)

ProteinSynonymsTaxonomy
Histone-lysine N-methyltransferase 2DLysine N-methyltransferase 2D; EC 2.1.1.354; ALL1-related protein; Myeloid/lymphoid or mixed-lineage leukemia protein 2Homo sapiens (human)
Histone-lysine N-methyltransferase 2BLysine N-methyltransferase 2B; EC 2.1.1.354; Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; WW domain-binding protein 7; WBP-7Homo sapiens (human)
Methylcytosine dioxygenase TET3EC 1.14.11.n2Homo sapiens (human)
PHD finger protein 1Protein PHF1; hPHF1; Polycomb-like protein 1; hPCl1Homo sapiens (human)
PC4 and SFRS1-interacting proteinCLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52Homo sapiens (human)
PHD finger protein 19Polycomb-like protein 3; hPCL3Homo sapiens (human)
Methylcytosine dioxygenase TET1EC 1.14.11.n2; CXXC-type zinc finger protein 6; Leukemia-associated protein with a CXXC domain; Ten-eleven translocation 1 gene proteinHomo sapiens (human)
Protein dpy-30 homologDpy-30-like protein; Dpy-30LHomo sapiens (human)
CXXC-type zinc finger protein 1CpG-binding protein; PHD finger and CXXC domain-containing protein 1Homo sapiens (human)
Methyl-CpG-binding domain protein 2Demethylase; DMTase; Methyl-CpG-binding protein MBD2Homo sapiens (human)
Tyrosine-protein kinase BAZ1BEC 2.7.10.2; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2Homo sapiens (human)
Histone-lysine N-methyltransferase SETD1BEC 2.1.1.354; Lysine N-methyltransferase 2G; SET domain-containing protein 1B; hSET1BHomo sapiens (human)
DNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
Glycogen synthase kinase-3 betaGSK-3 beta; EC 2.7.11.26; Serine/threonine-protein kinase GSK3B; 2.7.11.1Homo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
Histone deacetylase 2HD2; EC 3.5.1.98Homo sapiens (human)
NAD-dependent protein deacetylase sirtuin-1hSIRT1; EC 2.3.1.286; NAD-dependent protein deacylase sirtuin-1; 2.3.1.-; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2Homo sapiens (human)
General transcription and DNA repair factor IIH helicase subunit XPBTFIIH subunit XPB; EC 3.6.4.12; Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH 89 kDa subunit; TFIIH p8Homo sapiens (human)
DNA (cytosine-5)-methyltransferase 1Dnmt1; EC 2.1.1.37; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; MCMTHomo sapiens (human)
Histone acetyltransferase p300p300 HAT; EC 2.3.1.48; E1A-associated protein p300; Histone butyryltransferase p300; 2.3.1.-; Histone crotonyltransferase p300; 2.3.1.-; Protein 2-hydroxyisobutyryltransferase p300; 2.3.1.-; Protein propionyltransferase p300; 2.3.1.-Homo sapiens (human)
Histone acetyltransferase KAT2BEC 2.3.1.48; Histone acetyltransferase PCAF; Histone acetylase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; P/CAF; Spermidine acetyltransferase KAT2B; 2.3.1.57Homo sapiens (human)
Histone-lysine N-methyltransferase EHMT2EC 2.1.1.-; Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; Lysine N-methyltransferase 1C; Protein G9aHomo sapiens (human)
DNA (cytosine-5)-methyltransferase 3BDnmt3b; EC 2.1.1.37; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIBHomo sapiens (human)
Methylcytosine dioxygenase TET2EC 1.14.11.n2Homo sapiens (human)
YEATS domain-containing protein 2Homo sapiens (human)
Chromobox protein homolog 3HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 proteinHomo sapiens (human)
TATA box-binding protein-associated factor RNA polymerase I subunit ARNA polymerase I-specific TBP-associated factor 48 kDa; TAFI48; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription factor SL1; Transcription initiation factor SL1/TIF-IB subunit AHomo sapiens (human)
Nucleolar RNA helicase 2EC 3.6.4.13; DEAD box protein 21; Gu-alpha; Nucleolar RNA helicase Gu; Nucleolar RNA helicase II; RH II/GuHomo sapiens (human)
Protein Dr1Down-regulator of transcription 1; Negative cofactor 2-beta; NC2-beta; TATA-binding protein-associated phosphoproteinHomo sapiens (human)
Splicing factor 3B subunit 1Pre-mRNA-splicing factor SF3b 155 kDa subunit; SF3b155; Spliceosome-associated protein 155; SAP 155Homo sapiens (human)
Histone acetyltransferase KAT2AEC 2.3.1.48; General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; hGCN5; Histone glutaryltransferase KAT2A; 2.3.1.-; Histone succinyltransferase KAT2A; 2.3.1.-; Lysine acetyltransferase 2A; STAF97Homo sapiens (human)
Threonine aspartase 1Taspase-1; EC 3.4.25.-Homo sapiens (human)
Histone-lysine N-methyltransferase 2CLysine N-methyltransferase 2C; EC 2.1.1.354; Homologous to ALR protein; Myeloid/lymphoid or mixed-lineage leukemia protein 3Homo sapiens (human)
Lysine-specific demethylase 6AEC 1.14.11.68; Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; [histone H3]-trimethyl-L-lysine(27) demethylase 6AHomo sapiens (human)
E3 ubiquitin-protein ligase UHRF1EC 2.3.2.27; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; Transcription factor ICBP90; Ubiquitin-like PHD and RING finHomo sapiens (human)
Histone acetyltransferase KAT8EC 2.3.1.48; Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOFHomo sapiens (human)
SAGA-associated factor 29Coiled-coil domain-containing protein 101; SAGA complex-associated factor 29Homo sapiens (human)
Histone-lysine N-methyltransferase SUV39H1EC 2.1.1.355; Histone H3-K9 methyltransferase 1; H3-K9-HMTase 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Suppressor of variegation 3-9 homolog 1; Su(var)3-9 homolog 1Homo sapiens (human)
Polycomb protein EEDhEED; Embryonic ectoderm development protein; WD protein associating with integrin cytoplasmic tails 1; WAIT-1Homo sapiens (human)
Actin, cytoplasmic 1Beta-actinHomo sapiens (human)
WD repeat-containing protein 5BMP2-induced 3-kb gene proteinHomo sapiens (human)
Histone H4Homo sapiens (human)
Histone-lysine N-methyltransferase 2ALysine N-methyltransferase 2A; EC 2.1.1.354; ALL-1; CXXC-type zinc finger protein 7; Myeloid/lymphoid or mixed-lineage leukemia; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Trithorax-like protein; Zinc finger protein HRXHomo sapiens (human)
Histone-binding protein RBBP4Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48Homo sapiens (human)
Histone-lysine N-methyltransferase EZH2EC 2.1.1.356; ENX-1; Enhancer of zeste homolog 2; Lysine N-methyltransferase 6Homo sapiens (human)
Histone-binding protein RBBP7Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46Homo sapiens (human)
Zinc finger protein AEBP2Adipocyte enhancer-binding protein 2; AE-binding protein 2Homo sapiens (human)
DNA (cytosine-5)-methyltransferase 3ADnmt3a; EC 2.1.1.37; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIAHomo sapiens (human)
Retinoblastoma-binding protein 5RBBP-5; Retinoblastoma-binding protein RBQ-3Homo sapiens (human)
Bromodomain adjacent to zinc finger domain protein 2ATranscription termination factor I-interacting protein 5; TTF-I-interacting protein 5; Tip5; hWALp3Homo sapiens (human)
General transcription and DNA repair factor IIH helicase subunit XPDTFIIH subunit XPD; EC 3.6.4.12; Basic transcription factor 2 80 kDa subunit; BTF2 p80; CXPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; TFIIH basal transcription factor complex 80 kDa subunit; TFIIH 80 kDa subunit; TFHomo sapiens (human)
Host cell factor 1HCF; HCF-1; C1 factor; CFF; VCAF; VP16 accessory proteinHomo sapiens (human)
WD repeat-containing protein 82Protein TMEM113; Swd2Homo sapiens (human)
MeninHomo sapiens (human)
DNA-directed RNA polymerase I subunit RPA1RNA polymerase I subunit A1; EC 2.7.7.6; A190; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; RNA polymerase I 194 kDa subunit; RPA194Homo sapiens (human)
Polycomb protein SUZ12Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homologHomo sapiens (human)
Set1/Ash2 histone methyltransferase complex subunit ASH2ASH2-like proteinHomo sapiens (human)
Metal-response element-binding transcription factor 2Metal regulatory transcription factor 2; Metal-response element DNA-binding protein M96; Polycomb-like protein 2; hPCl2Homo sapiens (human)
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitEC 2.4.1.255; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit; OGTHomo sapiens (human)
Histone deacetylase complex subunit SAP130130 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p130Homo sapiens (human)
Histone-lysine N-methyltransferase SETD1AEC 2.1.1.354; Lysine N-methyltransferase 2F; SET domain-containing protein 1A; hSET1A; Set1/Ash2 histone methyltransferase complex subunit SET1Homo sapiens (human)
PHD finger protein 20Glioma-expressed antigen 2; Hepatocellular carcinoma-associated antigen 58; Novel zinc finger protein; Transcription factor TZPHomo sapiens (human)
PAXIP1-associated glutamate-rich protein 1Glutamate-rich coactivator interacting with SRC1; GAS; PAXIP1-associated protein 1; PTIP-associated protein 1Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC4RNA polymerases I, II, and III subunit ABC4; ABC10-alpha; DNA-directed RNA polymerase II subunit K; RNA polymerase II 7.0 kDa subunit; RPB7.0; RPB10alphaHomo sapiens (human)
Protein JumonjiJumonji/ARID domain-containing protein 2Homo sapiens (human)
Protein DEKHomo sapiens (human)
Histone deacetylase complex subunit SAP1818 kDa Sin3-associated polypeptide; 2HOR0202; Cell growth-inhibiting gene 38 protein; Sin3-associated polypeptide p18Homo sapiens (human)
DNA-directed RNA polymerases I and III subunit RPAC1DNA-directed RNA polymerase I subunit C; RNA polymerases I and III subunit AC1; AC40; DNA-directed RNA polymerases I and III 40 kDa polypeptide; RPA40; RPA39; RPC40Homo sapiens (human)
DNA-directed RNA polymerase I subunit RPA34A34.5; Antisense to ERCC-1 protein; ASE-1; CD3-epsilon-associated protein; CD3E-associated protein; DNA-directed RNA polymerase I subunit G; RNA polymerase I-associated factor PAF49Homo sapiens (human)
Ribosomal RNA-processing protein 8EC 2.1.1.-; Cerebral protein 1; NucleomethylinHomo sapiens (human)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; EC 3.6.4.-; Sucrose nonfermenting protein 2 homolog; hSNF2HHomo sapiens (human)
Histone deacetylase complex subunit SAP3030 kDa Sin3-associated polypeptide; Sin3 corepressor complex subunit SAP30; Sin3-associated polypeptide p30Homo sapiens (human)
Transcriptional adapter 2-alphaTranscriptional adapter 2-like; ADA2-like proteinHomo sapiens (human)
Transcriptional adapter 3ADA3 homolog; hADA3; STAF54; Transcriptional adapter 3-like; ADA3-like proteinHomo sapiens (human)
Methyl-CpG-binding domain protein 3Methyl-CpG-binding protein MBD3Homo sapiens (human)
Nucleolar transcription factor 1Autoantigen NOR-90; Upstream-binding factor 1; UBF-1Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC1RNA polymerases I, II, and III subunit ABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; RPB5 homolog; XAP4Homo sapiens (human)
TATA-box-binding proteinTATA sequence-binding protein; TATA-binding factor; TATA-box factor; Transcription initiation factor TFIID TBP subunitHomo sapiens (human)
General transcription factor IIH subunit 1Basic transcription factor 2 62 kDa subunit; BTF2 p62; General transcription factor IIH polypeptide 1; TFIIH basal transcription factor complex p62 subunitHomo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC3RNA polymerases I, II, and III subunit ABC3; DNA-directed RNA polymerase II subunit H; DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide; RPB17; RPB8 homolog; hRPB8Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC2RNA polymerases I, II, and III subunit ABC2; DNA-directed RNA polymerase II subunit F; DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide; RPABC14.4; RPB14.4; RPB6 homolog; RPC15Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC5RNA polymerases I, II, and III subunit ABC5; DNA-directed RNA polymerase III subunit L; RNA polymerase II 7.6 kDa subunit; RPB7.6; RPB10 homologHomo sapiens (human)
DNA excision repair protein ERCC-6EC 3.6.4.-; ATP-dependent helicase ERCC6; Cockayne syndrome protein CSBHomo sapiens (human)
G/T mismatch-specific thymine DNA glycosylaseEC 3.2.2.29; Thymine-DNA glycosylase; hTDGHomo sapiens (human)
General transcription factor IIH subunit 2Basic transcription factor 2 44 kDa subunit; BTF2 p44; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunitHomo sapiens (human)
General transcription factor IIH subunit 3Basic transcription factor 2 34 kDa subunit; BTF2 p34; General transcription factor IIH polypeptide 3; TFIIH basal transcription factor complex p34 subunitHomo sapiens (human)
Nuclear receptor coactivator 6Activating signal cointegrator 2; ASC-2; Amplified in breast cancer protein 3; Cancer-amplified transcriptional coactivator ASC-2; Nuclear receptor coactivator RAP250; NRC RAP250; Nuclear receptor-activating protein, 250 kDa; Peroxisome proliferator-activHomo sapiens (human)
Transcription termination factor 1TTF-1; RNA polymerase I termination factor; Transcription termination factor I; TTF-IHomo sapiens (human)
TATA box-binding protein-associated factor RNA polymerase I subunit CRNA polymerase I-specific TBP-associated factor 110 kDa; TAFI110; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit CHomo sapiens (human)
DNA-directed RNA polymerase I subunit RPA43DNA-directed RNA polymerase I subunit F; Twist neighbor proteinHomo sapiens (human)
AT-rich interactive domain-containing protein 4BARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Breast cancer-associated antigen BRCAA1; Histone deacetylase complex subunit SAP180; Retinoblastoma-binding protein 1-like 1Homo sapiens (human)
TATA box-binding protein-associated factor RNA polymerase I subunit BRNA polymerase I-specific TBP-associated factor 63 kDa; TAFI63; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit BHomo sapiens (human)
PAX-interacting protein 1PAX transactivation activation domain-interacting proteinHomo sapiens (human)
General transcription factor IIH subunit 5General transcription factor IIH polypeptide 5; TFB5 ortholog; TFIIH basal transcription factor complex TTD-A subunitHomo sapiens (human)
KAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1; MSL1 homolog 1; hMSL1v1; NSL complex protein NSL1; Non-specific lethal 1 homologHomo sapiens (human)
ZZ-type zinc finger-containing protein 3Homo sapiens (human)
General transcription factor IIH subunit 4Basic transcription factor 2 52 kDa subunit; BTF2 p52; General transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunitHomo sapiens (human)
Microspherule protein 158 kDa microspherule protein; Cell cycle-regulated factor p78; INO80 complex subunit J; MCRS2Homo sapiens (human)
Myb-binding protein 1AHomo sapiens (human)
DNA-directed RNA polymerase I subunit RPA49RNA polymerase I subunit A49; DNA-directed RNA polymerase I subunit E; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53Homo sapiens (human)
TATA box-binding protein-associated factor RNA polymerase I subunit DRNA polymerase I-specific TBP-associated factor 41 kDa; TAFI41; TATA box-binding protein-associated factor 1D; TBP-associated factor 1D; Transcription initiation factor SL1/TIF-IB subunit DHomo sapiens (human)
Sin3 histone deacetylase corepressor complex component SDS345 kDa Sin3-associated polypeptide; Suppressor of defective silencing 3 protein homologHomo sapiens (human)
Cysteine-rich protein 2-binding proteinCSRP2-binding protein; ADA2A-containing complex subunit 2; ATAC2; CRP2-binding partner; CRP2BP; Lysine acetyltransferase 14Homo sapiens (human)
KAT8 regulatory NSL complex subunit 2NSL complex protein NSL2; Non-specific lethal 2 homologHomo sapiens (human)
DNA-directed RNA polymerase I subunit RPA2RNA polymerase I subunit 2; EC 2.7.7.6; DNA-directed RNA polymerase I 135 kDa polypeptide; RPA135Homo sapiens (human)
Histone deacetylase complex subunit SAP30LHCV non-structural protein 4A-transactivated protein 2; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-likeHomo sapiens (human)
MAP3K12-binding inhibitory protein 1MAPK upstream kinase-binding inhibitory protein; MUK-binding inhibitory proteinHomo sapiens (human)
DNA-directed RNA polymerase I subunit RPA12DNA-directed RNA polymerase I subunit H; Zinc ribbon domain-containing protein 1Homo sapiens (human)
KAT8 regulatory NSL complex subunit 3NSL complex protein NSL3; Non-specific lethal 3 homolog; Serum inhibited-related protein; Testis development protein PRTDHomo sapiens (human)
SAP30-binding proteinTranscriptional regulator protein HCNGPHomo sapiens (human)
Protein POLR1D, isoform 2Homo sapiens (human)

Compounds (15)

CompoundDescription
Succinate
acetic acidProduct of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
o-acetyl-adp-riboseAn acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction.
5-formylcytosinestructure in first source
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
alpha-Ketoglutarate
sofosbuvirA uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
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