| Protein | Synonyms | Taxonomy |
|---|
| Cholesterol 24-hydroxylase | CH24H; EC 1.14.14.25; Cholesterol 24-monooxygenase; Cholesterol 24S-hydroxylase; Cytochrome P450 46A1 | Homo sapiens (human) |
| Steroid 21-hydroxylase | EC 1.14.14.16; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B | Homo sapiens (human) |
| Bile acid receptor | Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14 | Homo sapiens (human) |
| Aromatase | EC 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase | Homo sapiens (human) |
| Cytochrome P450 11B2, mitochondrial | Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; CYPXIB2; Corticosterone 18-monooxygenase, CYP11B2; 1.14.15.5; Cytochrome P-450Aldo; Cytochrome P-450C18; Steroid 11-beta-hydroxylase, CYP11B2; 1.14.15.4; Steroid 18-hydroxylase | Homo sapiens (human) |
| Retinoic acid receptor RXR-alpha | Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha | Homo sapiens (human) |
| Cytochrome P450 1B1 | EC 1.14.14.1; CYPIB1; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152 | Homo sapiens (human) |
| Lanosterol 14-alpha demethylase | LDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase | Homo sapiens (human) |
| Aryl hydrocarbon receptor | Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76 | Homo sapiens (human) |
| Sterol 26-hydroxylase, mitochondrial | EC 1.14.15.15; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase | Homo sapiens (human) |
| Nuclear receptor coactivator 1 | NCoA-1; EC 2.3.1.48; Class E basic helix-loop-helix protein 74; bHLHe74; Protein Hin-2; RIP160; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; SRC-1 | Homo sapiens (human) |
| Nuclear receptor coactivator 2 | NCoA-2; Class E basic helix-loop-helix protein 75; bHLHe75; Transcriptional intermediary factor 2; hTIF2 | Homo sapiens (human) |
| Cholesterol side-chain cleavage enzyme, mitochondrial | EC 1.14.15.6; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc) | Homo sapiens (human) |
| Pro-opiomelanocortin | POMC; Corticotropin-lipotropin | Homo sapiens (human) |
| NADPH:adrenodoxin oxidoreductase, mitochondrial | AR; Adrenodoxin reductase; EC 1.18.1.6; Ferredoxin--NADP(+) reductase; Ferredoxin reductase | Homo sapiens (human) |
| Aryl hydrocarbon receptor repressor | AhR repressor; AhRR; Class E basic helix-loop-helix protein 77; bHLHe77 | Homo sapiens (human) |
| 24-hydroxycholesterol 7-alpha-hydroxylase | EC 1.14.14.26; Cytochrome P450 39A1; hCYP39A1; Oxysterol 7-alpha-hydroxylase | Homo sapiens (human) |
| Cytochrome P450 4V2 | Docosahexaenoic acid omega-hydroxylase CYP4V2; 1.14.14.79; Long-chain fatty acid omega-monooxygenase; 1.14.14.80 | Homo sapiens (human) |
| Compound | Description |
|---|
| hydronium ion | |
| Hydrocortisone | The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. |
| Estradiol | The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. |
| estrone | An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. |
| Progesterone | The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS. |
| Cholesterol | The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. |
| desoxycorticosterone | A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE |
| pregnenolone | A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| 18-hydroxycorticosterone | 11 beta,18,21-Trihydroxypregn-4-ene-3,20-dione. |
| 7,25-dihydroxycholesterol | has various immunosupressive effects; RN given refers to (3beta)-isomer; RN for cpd without isomeric designation not available 12/88 |
| 24-hydroxycholesterol | |
| 7 alpha-hydroxy-4-cholesten-3-one | structure |
| isocaproaldehyde | produced from side-chain cleavage of 20,22-dihydroxycholesterol |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| formate | |
| 7 alpha,12 alpha-dihydroxy-5-cholesten-3-one | inermediate in bile acid biosynthesis |
| cortodoxone | 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities. |
| 4,4-dimethylcholesta-8,14,24-trienol | a meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer |
| 4-hydroxyestradiol | catechol estrogen |
| aldosterone | A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. |
| 20,22-dihydroxycholesterol | RN given refers to (3beta,22R)-isomer |
| cholest-5-en-3 beta,7 alpha-diol | substrate for hydroxysteroid dehydrogenase; RN given refers to (3beta,7alpha)-isomer |
| 7 alpha,26-dihydroxy-4-cholesten-3-one | |
| lanosterol | A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS. |
| corticosterone | An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437) |
| creolin | from refined coal tar oils |
| androstenedione | A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL. |
| 25-hydroxycholesterol | |
| cholest-5-ene-3 beta,26-diol | isolated from human brain |