Pathways > Eicosanoid ligand-binding receptors
Page last updated: 2024-10-06

Eicosanoid ligand-binding receptors

Proteins (11)

ProteinSynonymsTaxonomy
Thromboxane A2 receptor TXA2-R; Prostanoid TP receptorHomo sapiens (human)
Cysteinyl leukotriene receptor 2CysLTR2; G-protein coupled receptor GPCR21; hGPCR21; G-protein coupled receptor HG57; HPN321Homo sapiens (human)
Prostaglandin E2 receptor EP1 subtypePGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptorHomo sapiens (human)
Prostaglandin F2-alpha receptorPGF receptor; PGF2-alpha receptor; Prostanoid FP receptorHomo sapiens (human)
Prostaglandin E2 receptor EP3 subtypePGE receptor EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; Prostanoid EP3 receptorHomo sapiens (human)
Prostacyclin receptorProstaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptorHomo sapiens (human)
Prostaglandin D2 receptor 2Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44Homo sapiens (human)
Prostaglandin D2 receptorPGD receptor; PGD2 receptor; Prostanoid DP receptorHomo sapiens (human)
Oxoeicosanoid receptor 15-oxo-ETE G-protein coupled receptor; G-protein coupled receptor 170; G-protein coupled receptor R527; G-protein coupled receptor TG1019Homo sapiens (human)
Cysteinyl leukotriene receptor 1CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81Homo sapiens (human)
Uracil nucleotide/cysteinyl leukotriene receptorUDP/CysLT receptor; G-protein coupled receptor 17; P2Y-like receptor; R12Homo sapiens (human)

Compounds (7)

CompoundDescription
dinoprostoneThe most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
dinoprostA naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
epoprostenolA prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
leukotriene b4The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
thromboxane a2An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
5-oxo-6,8,11,14-eicosatetraenoic acidRN given is for cpd without isomeric designation; an arachidonate metabolite which stimulates neutrophils to mobilize Ca and promotes PMN degranulation responses
prostaglandin d2The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
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