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Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists

Proteins (4)

ProteinSynonymsTaxonomy
Nuclear receptor subfamily 1 group I member 2Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXRHomo sapiens (human)
Peroxisome proliferator-activated receptor deltaPPAR-delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-betaHomo sapiens (human)
Peroxisome proliferator-activated receptor alphaPPAR-alpha; Nuclear receptor subfamily 1 group C member 1Homo sapiens (human)
Scavenger receptor class B member 1SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BIHomo sapiens (human)

Compounds (13)

CompoundDescription
apixabanan antithrombotic agent
n-Butyrate
anisindionestructure
phenindioneAn indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
dicumarolAn oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
acenocoumarolA coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)
phenprocoumonCoumarin derivative that acts as a long acting oral anticoagulant.
tioclomarol
vitamin k1 hydroquinonemetabolite of vitamin K1 & vitamin K1 2,3-epoxide
diphenadionemajor descriptor (66-86); on-line search PHENINDIONE (66-74); PHENINDIONE/AA (75-86); INDEX MEDICUS search DIPHENADIONE (66-86); RN given refers to parent cpd
pindoneRN given refers to parent cpd; structure
Vitamin K 2A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora.
lithocholic acidA bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.