| Protein | Synonyms | Taxonomy |
|---|---|---|
| Epidermal growth factor receptor | EC 2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 | Homo sapiens (human) |
| RAF proto-oncogene serine/threonine-protein kinase | EC 2.7.11.1; Proto-oncogene c-RAF; cRaf; Raf-1 | Homo sapiens (human) |
| Protein kinase C beta type | PKC-B; PKC-beta; EC 2.7.11.13 | Homo sapiens (human) |
| Protein kinase C alpha type | PKC-A; PKC-alpha; EC 2.7.11.13 | Homo sapiens (human) |
| Mitogen-activated protein kinase 3 | MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1 | Homo sapiens (human) |
| Dual specificity mitogen-activated protein kinase kinase 1 | MAP kinase kinase 1; MAPKK 1; MKK1; EC 2.7.12.2; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1 | Homo sapiens (human) |
| Mitogen-activated protein kinase kinase kinase 1 | EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1 | Homo sapiens (human) |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1 | Homo sapiens (human) |
| Transcription factor AP-1 | Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 | Homo sapiens (human) |
| Tyrosine-protein kinase JAK1 | EC 2.7.10.2; Janus kinase 1; JAK-1 | Homo sapiens (human) |
| SHC-transforming protein 1 | SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1 | Homo sapiens (human) |
| Signal transducer and activator of transcription 3 | Acute-phase response factor | Homo sapiens (human) |
| Mitogen-activated protein kinase 8 | MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1 | Homo sapiens (human) |
| Growth factor receptor-bound protein 2 | Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 | Homo sapiens (human) |
| Casein kinase II subunit alpha | CK II alpha; EC 2.7.11.1 | Homo sapiens (human) |
| Son of sevenless homolog 1 | SOS-1 | Homo sapiens (human) |
| Serum response factor | SRF | Homo sapiens (human) |
| Signal transducer and activator of transcription 2 | p113 | Homo sapiens (human) |
| GTPase HRas | EC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras | Homo sapiens (human) |
| Pro-epidermal growth factor | EGF | Homo sapiens (human) |
| Signal transducer and activator of transcription 1-alpha/beta | Transcription factor ISGF-3 components p91/p84 | Homo sapiens (human) |
| Signal transducer and activator of transcription 6 | IL-4 Stat | Homo sapiens (human) |
| Dual specificity mitogen-activated protein kinase kinase 4 | MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK | Homo sapiens (human) |
| Proto-oncogene c-Fos | Cellular oncogene fos; G0/G1 switch regulatory protein 7 | Homo sapiens (human) |
| ETS domain-containing protein Elk-1 | Homo sapiens (human) | |
| Ras GTPase-activating protein 1 | GAP; GTPase-activating protein; RasGAP; Ras p21 protein activator; p120GAP | Homo sapiens (human) |
| Compound | Description |
|---|---|
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| inositol 1,4,5-trisphosphate | Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. |
| Phosphatidylinositol 4,5-Diphosphate | A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994) |