Page last updated: 2024-10-06

Drug resistance of PDGFR mutants

Proteins (1)

ProteinSynonymsTaxonomy
Platelet-derived growth factor receptor alphaPDGF-R-alpha; PDGFR-alpha; EC 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived Homo sapiens (human)

Compounds (2)

CompoundDescription
regorafenibhas both antiangiogenic and antineoplastic activities; structure in first source
sorafenibA niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.