Page last updated: 2024-10-06

Drug resistance of FLT3 mutants

Proteins (1)

ProteinSynonymsTaxonomy
Receptor-type tyrosine-protein kinase FLT3EC 2.7.10.1; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1Homo sapiens (human)

Compounds (4)

CompoundDescription
sorafenibA niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.
pexidartinibinhibits both CSF1R and c-kit receptor tyrosine kinase; structure in first source
midostaurin
kw 2449has both multikinase inhibitory activity and antineoplastic activity; structure in first source