Page last updated: 2024-10-06

Downregulation of SMAD2/3:SMAD4 transcriptional activity

Proteins (16)

ProteinSynonymsTaxonomy
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
Poly [ADP-ribose] polymerase 1PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; DNA ADP-ribosyltransferase PARP1; 2.4.2.-; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; 2.4.2.-Homo sapiens (human)
Protein phosphatase 1AEC 3.1.3.16; Protein phosphatase 2C isoform alpha; PP2C-alpha; Protein phosphatase IAHomo sapiens (human)
Probable ubiquitin carboxyl-terminal hydrolase FAF-XEC 3.4.19.12; Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-XHomo sapiens (human)
E3 ubiquitin-protein ligase SMURF2hSMURF2; EC 2.3.2.26; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2Homo sapiens (human)
Mothers against decapentaplegic homolog 3MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3Homo sapiens (human)
Mothers against decapentaplegic homolog 2MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2Homo sapiens (human)
Mothers against decapentaplegic homolog 7MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7Homo sapiens (human)
Mothers against decapentaplegic homolog 4MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4Homo sapiens (human)
E3 ubiquitin-protein ligase TRIM33EC 2.3.2.27; Ectodermin homolog; RET-fused gene 7 protein; Protein Rfg7; RING-type E3 ubiquitin transferase TRIM33; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33Homo sapiens (human)
SNW domain-containing protein 1Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; Ski-interacting proteinHomo sapiens (human)
E3 ubiquitin-protein ligase NEDD4-like EC 2.3.2.26; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; Nedd4-2Homo sapiens (human)
WW domain-containing transcription regulator protein 1Transcriptional coactivator with PDZ-binding motifHomo sapiens (human)
Protein ATP1B4X,K-ATPase subunit beta-m; X/potassium-transporting ATPase subunit beta-mHomo sapiens (human)

Compounds (6)

CompoundDescription
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.