Pathways > Downregulation of ERBB2 signaling
Page last updated: 2024-10-06
Downregulation of ERBB2 signaling
Proteins (11)
| Protein | Synonyms | Taxonomy |
|---|
| Receptor tyrosine-protein kinase erbB-2 | EC 2.7.10.1; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2 | Homo sapiens (human) |
| Heat shock protein HSP 90-alpha | EC 3.6.4.10; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38 | Homo sapiens (human) |
| Megakaryocyte-associated tyrosine-protein kinase | EC 2.7.10.2; CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK | Homo sapiens (human) |
| Ubiquitin carboxyl-terminal hydrolase 8 | EC 3.4.19.12; Deubiquitinating enzyme 8; Ubiquitin isopeptidase Y; hUBPy; Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8 | Homo sapiens (human) |
| Tyrosine-protein phosphatase non-receptor type 12 | EC 3.1.3.48; PTP-PEST; Protein-tyrosine phosphatase G1; PTPG1 | Homo sapiens (human) |
| Hsp90 co-chaperone Cdc37 | Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37 | Homo sapiens (human) |
| Tyrosine-protein phosphatase non-receptor type 18 | EC 3.1.3.48; Brain-derived phosphatase | Homo sapiens (human) |
| Erbin | Densin-180-like protein; Erbb2-interacting protein; Protein LAP2 | Homo sapiens (human) |
| E3 ubiquitin-protein ligase CHIP | EC 2.3.2.27; Antigen NY-CO-7; CLL-associated antigen KW-8; Carboxy terminus of Hsp70-interacting protein; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U box-containing protein 1 | Homo sapiens (human) |
| E3 ubiquitin-protein ligase NRDP1 | EC 2.3.2.27; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1 | Homo sapiens (human) |
| Cullin-5 | CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1 | Homo sapiens (human) |
Compounds (4)
| Compound | Description |
|---|
| Orthophosphate | |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |