Downregulation of ACE2 by SARS-CoV-2 spike protein

Proteins (5)

Protein	Synonyms	Taxonomy
Type-1 angiotensin II receptor	AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1	Homo sapiens (human)
Type-2 angiotensin II receptor	Angiotensin II type-2 receptor; AT2	Homo sapiens (human)
Angiotensin-converting enzyme 2	EC 3.4.17.23; Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme-related carboxypeptidase; ACE-related carboxypeptidase; 3.4.17.-; Metalloprotease MPROT15	Homo sapiens (human)
Spike glycoprotein	S glycoprotein; E2; Peplomer protein	Severe acute respiratory syndrome coronavirus 2
Angiotensin-converting enzyme		Homo sapiens (human)

Compounds (1)

Compound	Description
angiotensin ii	An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.

Compound

Description

angiotensin ii

An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.