| Protein | Synonyms | Taxonomy |
|---|
| Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | | Homo sapiens (human) |
| Serine hydroxymethyltransferase, mitochondrial | SHMT; EC 2.1.2.1; Glycine hydroxymethyltransferase; Serine methylase | Homo sapiens (human) |
| Serine hydroxymethyltransferase, cytosolic | SHMT; EC 2.1.2.1; Glycine hydroxymethyltransferase; Serine methylase | Homo sapiens (human) |
| Thymidylate synthase | TS; TSase; EC 2.1.1.45 | Homo sapiens (human) |
| Reduced folate transporter | FOLT; Intestinal folate carrier 1; IFC-1; Placental folate transporter; Reduced folate carrier protein; RFC; hRFC; Reduced folate transporter 1; RFT-1; Solute carrier family 19 member 1; hSLC19A1 | Homo sapiens (human) |
| Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 | NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein; MTHFD2-like | Homo sapiens (human) |
| Bifunctional purine biosynthesis protein ATIC | AICAR transformylase/inosine monophosphate cyclohydrolase; ATIC | Homo sapiens (human) |
| Formimidoyltransferase-cyclodeaminase | Formiminotransferase-cyclodeaminase; FTCD; LCHC1 | Homo sapiens (human) |
| Folate receptor alpha | FR-alpha; Adult folate-binding protein; FBP; Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18 | Homo sapiens (human) |
| Proton-coupled folate transporter | G21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1 | Homo sapiens (human) |
| Methionine synthase | MS; EC 2.1.1.13; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase | Homo sapiens (human) |
| Dihydropteridine reductase | EC 1.5.1.34; HDHPR; Quinoid dihydropteridine reductase; Short chain dehydrogenase/reductase family 33C member 1 | Homo sapiens (human) |
| C-1-tetrahydrofolate synthase, cytoplasmic | C1-THF synthase | Homo sapiens (human) |
| Cytosolic 10-formyltetrahydrofolate dehydrogenase | 10-FTHFDH; FDH; EC 1.5.1.6; Aldehyde dehydrogenase family 1 member L1 | Homo sapiens (human) |
| Methylenetetrahydrofolate reductase | EC 1.5.1.20 | Homo sapiens (human) |
| Mitochondrial 10-formyltetrahydrofolate dehydrogenase | Mitochondrial 10-FTHFDH; mtFDH; EC 1.5.1.6; Aldehyde dehydrogenase family 1 member L2 | Homo sapiens (human) |
| Trifunctional purine biosynthetic protein adenosine-3 | | Homo sapiens (human) |
| Dihydrofolate reductase | | Homo sapiens (human) |
| Compound | Description |
|---|
| 5-methyltetrahydrofolate | |
| folic acid | A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. |
| leucovorin | The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS. |
| Ammonium | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| glutamic acid | A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| methionine | A sulfur-containing essential L-amino acid that is important in many body functions. |
| glycine | A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. |
| dihydrofolate | RN given refers to (L)-isomer |
| 5,10-methylenetetrahydrofolate | |
| 5,6,7,8-tetrahydrofolic acid | RN given refers to (DL)-isomer |
| 5,10-methenyltetrahydrofolate | |
| Serine | A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids. |
| Homocysteine | A thiol-containing amino acid formed by a demethylation of METHIONINE. |
| thymidine monophosphate | 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety. |
| 5-formamidoimidazole-4-carboxamide ribotide | purine precursor |
| s-adenosylhomocysteine | 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. |
| 2'-deoxyuridylic acid | RN given refers to parent cpd |
| aminoimidazole carboxamide | An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases. |