Page last updated: 2024-10-06

Diseases of programmed cell death

Proteins (35)

ProteinSynonymsTaxonomy
Peroxiredoxin-2EC 1.11.1.24; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2Homo sapiens (human)
Amyloid-beta precursor proteinAPP; ABPP; APPI; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta A4 protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-IIHomo sapiens (human)
Cyclin-dependent-like kinase 5 EC 2.7.11.1; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunitHomo sapiens (human)
Caspase-8CASP-8; EC 3.4.22.61; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACHHomo sapiens (human)
Non-structural protein 1NS1; NS1AInfluenza A virus (A/Puerto Rico/8/1934(H1N1))
Tumor necrosis factor ligand superfamily member 6Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasLHomo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Calpain-1 catalytic subunitEC 3.4.22.52; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANPHomo sapiens (human)
DNA polymerase alpha catalytic subunitEC 2.7.7.7; DNA polymerase alpha catalytic subunit p180Homo sapiens (human)
M-phase inducer phosphatase 2EC 3.1.3.48; Dual specificity phosphatase Cdc25BHomo sapiens (human)
M-phase inducer phosphatase 3EC 3.1.3.48; Dual specificity phosphatase Cdc25CHomo sapiens (human)
Receptor-interacting serine/threonine-protein kinase 1EC 2.7.11.1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1Homo sapiens (human)
Cyclin-dependent kinase 5 activator 1CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunitHomo sapiens (human)
Ribonucleoside-diphosphate reductase large subunitR1; EC 1.17.4.1; Ribonucleotide reductase large subunitHuman alphaherpesvirus 1 strain 17
Forkhead box protein O3AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1Homo sapiens (human)
Peroxiredoxin-1EC 1.11.1.24; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; Thioredoxin-dependent peroxiredoxin 1Homo sapiens (human)
Mixed lineage kinase domain-like proteinhMLKLHomo sapiens (human)
Receptor-interacting serine/threonine-protein kinase 3EC 2.7.11.1; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3Homo sapiens (human)
Bcl-2-like protein 11Bcl2-L-11; Bcl2-interacting mediator of cell deathHomo sapiens (human)
Calpain-2 catalytic subunitEC 3.4.22.53; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; Calpain large polypeptide L2; Calpain-2 large subunit; Millimolar-calpain; M-calpainHomo sapiens (human)
M-phase inducer phosphatase 1EC 3.1.3.48; Dual specificity phosphatase Cdc25AHomo sapiens (human)
CalpastatinCalpain inhibitor; Sperm BS-17 componentHomo sapiens (human)
TNF receptor-associated factor 2EC 2.3.2.27; E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3Homo sapiens (human)
FAS-associated death domain proteinFAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; Protein FADDHomo sapiens (human)
14-3-3 protein epsilon14-3-3EHomo sapiens (human)
Superoxide dismutase [Mn], mitochondrialEC 1.15.1.1Homo sapiens (human)
Complement component 1 Q subcomponent-binding protein, mitochondrialASF/SF2-associated protein p32; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; gC1q-R protein; p33; SF2AP32Homo sapiens (human)
Golgin subfamily A member 2130 kDa cis-Golgi matrix protein; GM130; GM130 autoantigen; Golgin-95Homo sapiens (human)
Uncharacterized protein UL36Human herpesvirus 5 strain AD169
Lamin-B1Homo sapiens (human)
DNA primase small subunitEC 2.7.7.-; DNA primase 49 kDa subunit; p49Homo sapiens (human)
DNA primase large subunitDNA primase 58 kDa subunit; p58Homo sapiens (human)
DNA polymerase alpha subunit BDNA polymerase alpha 70 kDa subunitHomo sapiens (human)
Tumor necrosis factor receptor type 1-associated DEATH domain proteinTNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domainHomo sapiens (human)
ORF3a proteinAccessory protein 3a; Protein 3a; Protein U274; Protein X1Severe acute respiratory syndrome-related coronavirus

Compounds (10)

CompoundDescription
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
decitabineAn azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
deoxyguanosine triphosphate
thymidine 5'-triphosphateRN given refers to parent cpd
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
2'-deoxycytidine 5'-triphosphateRN given refers to unlabeled parent cpd
deoxyadenosine diphosphateRN given refers to parent cpd.