Page last updated: 2024-10-06

DNA IR-double strand breaks and cellular response via ATM

Proteins (54)

ProteinSynonymsTaxonomy
NibrinCell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1Homo sapiens (human)
Structural maintenance of chromosomes protein 1ASMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8Homo sapiens (human)
Exonuclease 1hExo1; EC 3.1.-.-; Exonuclease I; hExoIHomo sapiens (human)
Transcriptional coactivator YAP1Yes-associated protein 1; Protein yorkie homolog; Yes-associated protein YAP65 homologHomo sapiens (human)
Serine/threonine-protein kinase Chk1EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1Homo sapiens (human)
Tyrosine-protein kinase ABL1EC 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Cyclin-dependent-like kinase 5 EC 2.7.11.1; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunitHomo sapiens (human)
Serine/threonine-protein kinase 3EC 2.7.11.1; Mammalian STE20-like protein kinase 2; MST-2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1Homo sapiens (human)
Breast cancer type 2 susceptibility proteinFanconi anemia group D1 proteinHomo sapiens (human)
Mediator of DNA damage checkpoint protein 1Nuclear factor with BRCT domains 1Homo sapiens (human)
Double-strand break repair protein MRE11EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog AHomo sapiens (human)
Serine/threonine-protein kinase Chk2EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2Homo sapiens (human)
Poly [ADP-ribose] polymerase 1PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; DNA ADP-ribosyltransferase PARP1; 2.4.2.-; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; 2.4.2.-Homo sapiens (human)
M-phase inducer phosphatase 3EC 3.1.3.48; Dual specificity phosphatase Cdc25CHomo sapiens (human)
Caspase-3CASP-3; EC 3.4.22.56; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1Homo sapiens (human)
Caspase-9CASP-9; EC 3.4.22.62; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6Homo sapiens (human)
BH3-interacting domain death agonistp22 BID; BIDHomo sapiens (human)
DNA-dependent protein kinase catalytic subunitDNA-PK catalytic subunit; DNA-PKcs; EC 2.7.11.1; DNPK1; p460Homo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
DNA repair protein RAD51 homolog 1HsRAD51; hRAD51; RAD51 homolog AHomo sapiens (human)
Apoptosis regulator BAX Bcl-2-like protein 4; Bcl2-L-4Homo sapiens (human)
Telomeric repeat-binding factor 2TTAGGG repeat-binding factor 2; Telomeric DNA-binding proteinHomo sapiens (human)
Heat shock factor protein 1HSF 1; Heat shock transcription factor 1; HSTF 1Homo sapiens (human)
Bcl-2 homologous antagonist/killerApoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7Homo sapiens (human)
Fanconi anemia group D2 proteinProtein FACD2Homo sapiens (human)
DNA repair protein RAD52 homologHomo sapiens (human)
SOSS complex subunit B1Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1Homo sapiens (human)
Apoptotic protease-activating factor 1APAF-1Homo sapiens (human)
Serine/threonine-protein kinase LATS1EC 2.7.11.1; Large tumor suppressor homolog 1; WARTS protein kinase; h-wartsHomo sapiens (human)
Proliferating cell nuclear antigenPCNA; CyclinHomo sapiens (human)
Breast cancer type 1 susceptibility proteinEC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1Homo sapiens (human)
Bloom syndrome proteinEC 3.6.4.12; DNA helicase, RecQ-like type 2; RecQ2; RecQ protein-like 3Homo sapiens (human)
Transcription factor E2F1E2F-1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1Homo sapiens (human)
TP53-binding protein 153BP1; p53-binding protein 1; p53BP1Homo sapiens (human)
Serine-protein kinase ATMEC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutatedHomo sapiens (human)
Serine/threonine-protein kinase ATREC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1Homo sapiens (human)
Histone acetyltransferase KAT5EC 2.3.1.48; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting proteinHomo sapiens (human)
Ras association domain-containing protein 1Homo sapiens (human)
Tumor suppressor ARFAlternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p14ARFHomo sapiens (human)
Transcription intermediary factor 1-betaTIF1-beta; E3 SUMO-protein ligase TRIM28; 2.3.2.27; KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; Tripartite motif-containing protein Homo sapiens (human)
TNF receptor-associated factor 6EC 2.3.2.27; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6Homo sapiens (human)
Tumor protein p73p53-like transcription factor; p53-related proteinHomo sapiens (human)
DNA repair protein RAD50hRAD50; EC 3.6.-.-Homo sapiens (human)
Cell cycle checkpoint protein RAD17hRad17; RF-C/activator 1 homologHomo sapiens (human)
E3 ubiquitin-protein ligase RNF8hRNF8; EC 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8Homo sapiens (human)
Actin-like protein 6A53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit KHomo sapiens (human)
Histone H2AXH2a/x; Histone H2A.XHomo sapiens (human)
DNA polymerase delta subunit 3Cell division control protein 27Schizosaccharomyces pombe 972h-
Telomere-associated protein RIF1Rap1-interacting factor 1 homologHomo sapiens (human)
MicrocephalinHomo sapiens (human)
Regulator of nonsense transcripts 1EC 3.6.4.-; ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog; hUpf1Homo sapiens (human)
Protein artemisEC 3.1.-.-; DNA cross-link repair 1C protein; Protein A-SCID; SNM1 homolog C; hSNM1C; SNM1-like proteinHomo sapiens (human)
Structural maintenance of chromosomes protein 3SMC protein 3; SMC-3; Basement membrane-associated chondroitin proteoglycan; Bamacan; Chondroitin sulfate proteoglycan 6; Chromosome-associated polypeptide; hCAPHomo sapiens (human)

Compounds (0)

CompoundDescription