Page last updated: 2024-10-06

DNA IR-damage and cellular response via ATR

Proteins (82)

ProteinSynonymsTaxonomy
DNA topoisomerase 2-binding protein 1DNA topoisomerase II-beta-binding protein 1; TopBP1; DNA topoisomerase II-binding protein 1Homo sapiens (human)
NibrinCell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1Homo sapiens (human)
Lys-63-specific deubiquitinase BRCC36EC 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36Homo sapiens (human)
Forkhead box protein M1Forkhead-related protein FKHL16; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; Transcription factor Trident; Winged-helix factor from INS-1 cellsHomo sapiens (human)
Structural maintenance of chromosomes protein 1ASMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8Homo sapiens (human)
ATR-interacting proteinATM and Rad3-related-interacting proteinHomo sapiens (human)
Fanconi anemia group J proteinProtein FACJ; EC 3.6.4.13; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1Homo sapiens (human)
Exonuclease 1hExo1; EC 3.1.-.-; Exonuclease I; hExoIHomo sapiens (human)
Serine/threonine-protein kinase Chk1EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Cyclin-dependent kinase 1CDK1; EC 2.7.11.22; EC 2.7.11.23; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinaseHomo sapiens (human)
Cyclin-dependent kinase 2EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinaseHomo sapiens (human)
Serine/threonine-protein kinase PLK1EC 2.7.11.21; Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13; STPK13Homo sapiens (human)
Werner syndrome ATP-dependent helicaseEC 3.6.4.12; DNA helicase, RecQ-like type 3; RecQ3; Exonuclease WRN; 3.1.-.-; RecQ protein-like 2Homo sapiens (human)
Breast cancer type 2 susceptibility proteinFanconi anemia group D1 proteinHomo sapiens (human)
Mediator of DNA damage checkpoint protein 1Nuclear factor with BRCT domains 1Homo sapiens (human)
Double-strand break repair protein MRE11EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog AHomo sapiens (human)
Serine/threonine-protein kinase Chk2EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2Homo sapiens (human)
DNA polymerase betaEC 2.7.7.7; EC 4.2.99.-Homo sapiens (human)
Poly [ADP-ribose] polymerase 1PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; DNA ADP-ribosyltransferase PARP1; 2.4.2.-; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; 2.4.2.-Homo sapiens (human)
Replication protein A 70 kDa DNA-binding subunitRP-A p70; Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding proteinHomo sapiens (human)
M-phase inducer phosphatase 3EC 3.1.3.48; Dual specificity phosphatase Cdc25CHomo sapiens (human)
Dual specificity protein kinase CLK2EC 2.7.12.1; CDC-like kinase 2Homo sapiens (human)
DNA-dependent protein kinase catalytic subunitDNA-PK catalytic subunit; DNA-PKcs; EC 2.7.11.1; DNPK1; p460Homo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
DNA repair protein RAD51 homolog 1HsRAD51; hRAD51; RAD51 homolog AHomo sapiens (human)
Tyrosyl-DNA phosphodiesterase 1Tyr-DNA phosphodiesterase 1; EC 3.1.4.-Homo sapiens (human)
B-cell lymphoma 6 proteinBCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51Homo sapiens (human)
DNA repair protein complementing XP-A cellsXeroderma pigmentosum group A-complementing proteinHomo sapiens (human)
DNA mismatch repair protein Msh2hMSH2; MutS protein homolog 2Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 D3EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme D3; 2.3.2.24; E2 ubiquitin-conjugating enzyme D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3Homo sapiens (human)
DNA cross-link repair 1A proteinSNM1 homolog A; hSNM1; hSNM1AHomo sapiens (human)
DNA replication licensing factor MCM2EC 3.6.4.12; Minichromosome maintenance protein 2 homolog; Nuclear protein BM28Homo sapiens (human)
BRCA1-associated RING domain protein 1BARD-1; EC 2.3.2.27; RING-type E3 ubiquitin transferase BARD1Homo sapiens (human)
Fanconi anemia group D2 proteinProtein FACD2Homo sapiens (human)
NF-kappa-B essential modulatorNEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifierHomo sapiens (human)
DNA repair protein RAD52 homologHomo sapiens (human)
Protein phosphatase 1DEC 3.1.3.16; Protein phosphatase 2C isoform delta; PP2C-delta; Protein phosphatase magnesium-dependent 1 delta; p53-induced protein phosphatase 1Homo sapiens (human)
Proliferating cell nuclear antigenPCNA; CyclinHomo sapiens (human)
Breast cancer type 1 susceptibility proteinEC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1Homo sapiens (human)
ATP-dependent DNA helicase Q1EC 3.6.4.12; DNA helicase, RecQ-like type 1; RecQ1; DNA-dependent ATPase Q1; RecQ protein-like 1Homo sapiens (human)
Transcription factor E2F1E2F-1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1Homo sapiens (human)
TP53-binding protein 153BP1; p53-binding protein 1; p53BP1Homo sapiens (human)
Serine/threonine-protein kinase ATREC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1Homo sapiens (human)
DNA polymerase nuEC 2.7.7.7Homo sapiens (human)
Transcription factor Sp1Homo sapiens (human)
Cell division control protein 45 homologPORC-PI-1Homo sapiens (human)
Flap endonuclease 1FEN-1; EC 3.1.-.-; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1Homo sapiens (human)
DNA mismatch repair protein Mlh1 MutL protein homolog 1Homo sapiens (human)
Cell cycle checkpoint protein RAD1hRAD1; EC 3.1.11.2; DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint proteinHomo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 1EC 3.4.19.12; Deubiquitinating enzyme 1; hUBP; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1Homo sapiens (human)
26S proteasome complex subunit SEM126S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 proteinHomo sapiens (human)
Protein PMLPromyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19Homo sapiens (human)
X-ray repair cross-complementing protein 5EC 3.6.4.-; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Lupus Ku autoantigen protein p86; NuHomo sapiens (human)
Transcription intermediary factor 1-betaTIF1-beta; E3 SUMO-protein ligase TRIM28; 2.3.2.27; KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; Tripartite motif-containing protein Homo sapiens (human)
Centrosomal protein of 164 kDaCep164Homo sapiens (human)
E3 ubiquitin-protein ligase HERC2EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2Homo sapiens (human)
DNA endonuclease RBBP8EC 3.1.-.-; CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2Homo sapiens (human)
DNA repair protein RAD50hRAD50; EC 3.6.-.-Homo sapiens (human)
Fanconi anemia group A proteinProtein FACAHomo sapiens (human)
Eukaryotic translation elongation factor 1 epsilon-1Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; Elongation factor p18; Multisynthase complex auxiliary component p18Homo sapiens (human)
Checkpoint protein HUS1hHUS1Homo sapiens (human)
Cell cycle checkpoint protein RAD17hRad17; RF-C/activator 1 homologHomo sapiens (human)
ATP-dependent DNA helicase Q4EC 3.6.4.12; DNA helicase, RecQ-like type 4; RecQ4; RTS; RecQ protein-like 4Homo sapiens (human)
ATP-dependent DNA helicase Q5EC 3.6.4.12; DNA helicase, RecQ-like type 5; RecQ5; RecQ protein-like 5Homo sapiens (human)
G2/mitotic-specific cyclin-ADrosophila melanogaster (fruit fly)
Replication protein A 32 kDa subunitRP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34Homo sapiens (human)
Histone H2AXH2a/x; Histone H2A.XHomo sapiens (human)
G2/mitotic-specific cyclin-BDrosophila melanogaster (fruit fly)
DNA topoisomerase 3-alphaEC 5.6.2.1; DNA topoisomerase III alphaHomo sapiens (human)
E3 ubiquitin-protein ligase RFWD3EC 2.3.2.27; RING finger and WD repeat domain-containing protein 3; RING finger protein 201Homo sapiens (human)
BRCA1-A complex subunit Abraxas 1Coiled-coil domain-containing protein 98; Protein FAM175AHomo sapiens (human)
Partner and localizer of BRCA2Homo sapiens (human)
MicrocephalinHomo sapiens (human)
SWI/SNF complex subunit SMARCC2BRG1-associated factor 170; BAF170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2Homo sapiens (human)
Regulator of nonsense transcripts 1EC 3.6.4.-; ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog; hUpf1Homo sapiens (human)
BRCA1-A complex subunit RAP80Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1Homo sapiens (human)
Cell cycle checkpoint control protein RAD9AhRAD9; EC 3.1.11.2; DNA repair exonuclease rad9 homolog AHomo sapiens (human)
RecQ-mediated genome instability protein 1BLM-associated protein of 75 kDa; BLAP75; FAAP75Homo sapiens (human)
ClaspinhClaspinHomo sapiens (human)
Fanconi anemia group I proteinProtein FACIHomo sapiens (human)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1EC 3.6.4.-; HepA-related protein; hHARP; Sucrose nonfermenting protein 2-like 1Homo sapiens (human)

Compounds (0)

CompoundDescription