| Protein | Synonyms | Taxonomy |
|---|
| Nibrin | Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1 | Homo sapiens (human) |
| Lys-63-specific deubiquitinase BRCC36 | EC 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36 | Homo sapiens (human) |
| Serine/threonine-protein phosphatase 5 | PP5; EC 3.1.3.16; Protein phosphatase T; PP-T; PPT | Homo sapiens (human) |
| Small ubiquitin-related modifier 1 | SUMO-1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein UBL1 | Homo sapiens (human) |
| E3 ubiquitin-protein ligase RNF168 | hRNF168; EC 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168 | Homo sapiens (human) |
| BRISC and BRCA1-A complex member 1 | Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex | Homo sapiens (human) |
| BRISC and BRCA1-A complex member 2 | BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein | Homo sapiens (human) |
| Tyrosine-protein kinase BAZ1B | EC 2.7.10.2; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2 | Homo sapiens (human) |
| Tyrosine-protein kinase ABL1 | EC 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150 | Homo sapiens (human) |
| Cellular tumor antigen p53 | Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 | Homo sapiens (human) |
| Mediator of DNA damage checkpoint protein 1 | Nuclear factor with BRCT domains 1 | Homo sapiens (human) |
| Double-strand break repair protein MRE11 | EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A | Homo sapiens (human) |
| Serine/threonine-protein kinase Chk2 | EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2 | Homo sapiens (human) |
| Mitogen-activated protein kinase 8 | MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1 | Homo sapiens (human) |
| BRCA1-associated RING domain protein 1 | BARD-1; EC 2.3.2.27; RING-type E3 ubiquitin transferase BARD1 | Homo sapiens (human) |
| Histone-lysine N-methyltransferase NSD2 | EC 2.1.1.357; Multiple myeloma SET domain-containing protein; MMSET; Nuclear SET domain-containing protein 2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein | Homo sapiens (human) |
| Breast cancer type 1 susceptibility protein | EC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1 | Homo sapiens (human) |
| Ubiquitin-conjugating enzyme E2 N | EC 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N | Homo sapiens (human) |
| Histone H4 | | Homo sapiens (human) |
| TP53-binding protein 1 | 53BP1; p53-binding protein 1; p53BP1 | Homo sapiens (human) |
| Serine-protein kinase ATM | EC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutated | Homo sapiens (human) |
| Histone acetyltransferase KAT5 | EC 2.3.1.48; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein | Homo sapiens (human) |
| Ubiquitin carboxyl-terminal hydrolase BAP1 | EC 3.4.19.12; BRCA1-associated protein 1; Cerebral protein 6 | Homo sapiens (human) |
| SUMO-conjugating enzyme UBC9 | EC 2.3.2.-; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18 | Homo sapiens (human) |
| Importin subunit alpha-1 | Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha | Homo sapiens (human) |
| Amyloid-beta A4 precursor protein-binding family B member 1 | Protein Fe65 | Homo sapiens (human) |
| E3 ubiquitin-protein ligase HERC2 | EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2 | Homo sapiens (human) |
| DNA repair protein RAD50 | hRAD50; EC 3.6.-.- | Homo sapiens (human) |
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; EC 3.6.4.-; Sucrose nonfermenting protein 2 homolog; hSNF2H | Homo sapiens (human) |
| E3 ubiquitin-protein ligase RNF8 | hRNF8; EC 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8 | Homo sapiens (human) |
| Histone H2AX | H2a/x; Histone H2A.X | Homo sapiens (human) |
| UBX domain-containing protein 1 | SAPK substrate protein 1; UBA/UBX 33.3 kDa protein | Homo sapiens (human) |
| Ubiquitin-conjugating enzyme E2 variant 2 | DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible protein | Homo sapiens (human) |
| Histone H3.1t | H3/t; H3t; H3/g; Histone H3.4 | Homo sapiens (human) |
| BRCA1-A complex subunit Abraxas 1 | Coiled-coil domain-containing protein 98; Protein FAM175A | Homo sapiens (human) |
| E3 SUMO-protein ligase PIAS4 | EC 2.3.2.27; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma; RING-type E3 ubiquitin transferase PIAS4 | Homo sapiens (human) |
| BRCA1-A complex subunit RAP80 | Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1 | Homo sapiens (human) |
| Compound | Description |
|---|
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| Orthophosphate | |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |