DNA Double-Strand Break Repair

Proteins (103)

Protein	Synonyms	Taxonomy
DNA topoisomerase 2-binding protein 1	DNA topoisomerase II-beta-binding protein 1; TopBP1; DNA topoisomerase II-binding protein 1	Homo sapiens (human)
Nibrin	Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1	Homo sapiens (human)
Lys-63-specific deubiquitinase BRCC36	EC 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36	Homo sapiens (human)
Serine/threonine-protein phosphatase 5	PP5; EC 3.1.3.16; Protein phosphatase T; PP-T; PPT	Homo sapiens (human)
Small ubiquitin-related modifier 2	SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B; Smt3B	Homo sapiens (human)
Small ubiquitin-related modifier 1	SUMO-1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein UBL1	Homo sapiens (human)
E3 ubiquitin-protein ligase RNF168	hRNF168; EC 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168	Homo sapiens (human)
ATR-interacting protein	ATM and Rad3-related-interacting protein	Homo sapiens (human)
Fanconi anemia group J protein	Protein FACJ; EC 3.6.4.13; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1	Homo sapiens (human)
BRISC and BRCA1-A complex member 1	Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex	Homo sapiens (human)
BRISC and BRCA1-A complex member 2	BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein	Homo sapiens (human)
Tyrosine-protein kinase BAZ1B	EC 2.7.10.2; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2	Homo sapiens (human)
Exonuclease 1	hExo1; EC 3.1.-.-; Exonuclease I; hExoI	Homo sapiens (human)
DNA polymerase theta	EC 2.7.7.7; DNA polymerase eta	Homo sapiens (human)
Serine/threonine-protein kinase Chk1	EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1	Homo sapiens (human)
Tyrosine-protein kinase ABL1	EC 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150	Homo sapiens (human)
Cellular tumor antigen p53	Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	Homo sapiens (human)
Cyclin-dependent kinase 2	EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinase	Homo sapiens (human)
Werner syndrome ATP-dependent helicase	EC 3.6.4.12; DNA helicase, RecQ-like type 3; RecQ3; Exonuclease WRN; 3.1.-.-; RecQ protein-like 2	Homo sapiens (human)
Breast cancer type 2 susceptibility protein	Fanconi anemia group D1 protein	Homo sapiens (human)
Mediator of DNA damage checkpoint protein 1	Nuclear factor with BRCT domains 1	Homo sapiens (human)
Double-strand break repair protein MRE11	EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A	Homo sapiens (human)
Serine/threonine-protein kinase Chk2	EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2	Homo sapiens (human)
Replication protein A 70 kDa DNA-binding subunit	RP-A p70; Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding protein	Homo sapiens (human)
Mitogen-activated protein kinase 8	MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1	Homo sapiens (human)
DNA-dependent protein kinase catalytic subunit	DNA-PK catalytic subunit; DNA-PKcs; EC 2.7.11.1; DNPK1; p460	Homo sapiens (human)
DNA repair protein RAD51 homolog 1	HsRAD51; hRAD51; RAD51 homolog A	Homo sapiens (human)
DNA excision repair protein ERCC-1		Homo sapiens (human)
DNA ligase 3	EC 6.5.1.1; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3	Homo sapiens (human)
Replication factor C subunit 5	Activator 1 36 kDa subunit; A1 36 kDa subunit; Activator 1 subunit 5; Replication factor C 36 kDa subunit; RF-C 36 kDa subunit; RFC36	Homo sapiens (human)
DNA repair protein XRCC4	X-ray repair cross-complementing protein 4	Homo sapiens (human)
BRCA1-associated RING domain protein 1	BARD-1; EC 2.3.2.27; RING-type E3 ubiquitin transferase BARD1	Homo sapiens (human)
Protein timeless homolog	hTIM	Homo sapiens (human)
Histone-lysine N-methyltransferase NSD2	EC 2.1.1.357; Multiple myeloma SET domain-containing protein; MMSET; Nuclear SET domain-containing protein 2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein	Homo sapiens (human)
DNA repair protein RAD52 homolog		Homo sapiens (human)
DNA replication ATP-dependent helicase/nuclease DNA2	hDNA2; DNA replication ATP-dependent helicase-like homolog	Homo sapiens (human)
Breast cancer type 1 susceptibility protein	EC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1	Homo sapiens (human)
Bloom syndrome protein	EC 3.6.4.12; DNA helicase, RecQ-like type 2; RecQ2; RecQ protein-like 3	Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 N	EC 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N	Homo sapiens (human)
Histone H4		Homo sapiens (human)
TP53-binding protein 1	53BP1; p53-binding protein 1; p53BP1	Homo sapiens (human)
Serine-protein kinase ATM	EC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutated	Homo sapiens (human)
Serine/threonine-protein kinase ATR	EC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1	Homo sapiens (human)
NAD-dependent protein deacetylase sirtuin-6	EC 2.3.1.286; Regulatory protein SIR2 homolog 6; SIR2-like protein 6	Homo sapiens (human)
Histone acetyltransferase KAT5	EC 2.3.1.48; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein	Homo sapiens (human)
Flap endonuclease 1	FEN-1; EC 3.1.-.-; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1	Homo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase BAP1	EC 3.4.19.12; BRCA1-associated protein 1; Cerebral protein 6	Homo sapiens (human)
Regulator of telomere elongation helicase 1	EC 3.6.4.12; Novel helicase-like	Homo sapiens (human)
Cell cycle checkpoint protein RAD1	hRAD1; EC 3.1.11.2; DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint protein	Homo sapiens (human)
26S proteasome complex subunit SEM1	26S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 protein	Homo sapiens (human)
SUMO-conjugating enzyme UBC9	EC 2.3.2.-; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18	Homo sapiens (human)
X-ray repair cross-complementing protein 6	EC 3.6.4.-; EC 4.2.99.-; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA	Homo sapiens (human)
DNA repair endonuclease XPF	EC 3.1.-.-; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein	Homo sapiens (human)
X-ray repair cross-complementing protein 5	EC 3.6.4.-; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Lupus Ku autoantigen protein p86; Nu	Homo sapiens (human)
DNA ligase 4	EC 6.5.1.1; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4	Homo sapiens (human)
Importin subunit alpha-1	Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha	Homo sapiens (human)
DNA repair protein RAD51 homolog 2	R51H2; RAD51 homolog B; Rad51B; RAD51-like protein 1	Homo sapiens (human)
Amyloid-beta A4 precursor protein-binding family B member 1	Protein Fe65	Homo sapiens (human)
DNA repair protein RAD51 homolog 4	R51H3; RAD51 homolog D; RAD51-like protein 3; TRAD	Homo sapiens (human)
Structure-specific endonuclease subunit SLX4	BTB/POZ domain-containing protein 12	Homo sapiens (human)
E3 ubiquitin-protein ligase HERC2	EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2	Homo sapiens (human)
DNA endonuclease RBBP8	EC 3.1.-.-; CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2	Homo sapiens (human)
DNA repair protein RAD50	hRAD50; EC 3.6.-.-	Homo sapiens (human)
Probable crossover junction endonuclease EME2	EC 3.1.22.-	Homo sapiens (human)
Crossover junction endonuclease EME1	EC 3.1.22.-; MMS4 homolog; hMMS4	Homo sapiens (human)
Crossover junction endonuclease MUS81	EC 3.1.22.-	Homo sapiens (human)
DNA repair protein RAD51 homolog 3	R51H3; RAD51 homolog C; RAD51-like protein 2	Homo sapiens (human)
DNA repair protein XRCC3	X-ray repair cross-complementing protein 3	Homo sapiens (human)
DNA repair protein XRCC2	X-ray repair cross-complementing protein 2	Homo sapiens (human)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; EC 3.6.4.-; Sucrose nonfermenting protein 2 homolog; hSNF2H	Homo sapiens (human)
Checkpoint protein HUS1	hHUS1	Homo sapiens (human)
Cell cycle checkpoint protein RAD17	hRad17; RF-C/activator 1 homolog	Homo sapiens (human)
E3 ubiquitin-protein ligase RNF8	hRNF8; EC 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8	Homo sapiens (human)
Replication protein A 32 kDa subunit	RP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34	Homo sapiens (human)
Histone H2AX	H2a/x; Histone H2A.X	Homo sapiens (human)
DNA repair protein XRCC1	X-ray repair cross-complementing protein 1	Homo sapiens (human)
Replication protein A 14 kDa subunit	RP-A p14; Replication factor A protein 3; RF-A protein 3	Homo sapiens (human)
Replication factor C subunit 4	Activator 1 37 kDa subunit; A1 37 kDa subunit; Activator 1 subunit 4; Replication factor C 37 kDa subunit; RF-C 37 kDa subunit; RFC37	Homo sapiens (human)
Replication factor C subunit 2	Activator 1 40 kDa subunit; A1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40	Homo sapiens (human)
Replication factor C subunit 3	Activator 1 38 kDa subunit; A1 38 kDa subunit; Activator 1 subunit 3; Replication factor C 38 kDa subunit; RF-C 38 kDa subunit; RFC38	Homo sapiens (human)
Serine/threonine-protein phosphatase 4 catalytic subunit	PP4C; Pp4; EC 3.1.3.16; Protein phosphatase X; PP-X	Homo sapiens (human)
E3 ubiquitin-protein ligase RNF4	EC 2.3.2.27; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURF	Homo sapiens (human)
UBX domain-containing protein 1	SAPK substrate protein 1; UBA/UBX 33.3 kDa protein	Homo sapiens (human)
DNA topoisomerase 3-alpha	EC 5.6.2.1; DNA topoisomerase III alpha	Homo sapiens (human)
DNA repair-scaffolding protein	Scaffolding protein involved in DNA repair	Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 variant 2	DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible protein	Homo sapiens (human)
Histone H3.1t	H3/t; H3t; H3/g; Histone H3.4	Homo sapiens (human)
Telomere-associated protein RIF1	Rap1-interacting factor 1 homolog	Homo sapiens (human)
BRCA1-A complex subunit Abraxas 1	Coiled-coil domain-containing protein 98; Protein FAM175A	Homo sapiens (human)
PAX-interacting protein 1	PAX transactivation activation domain-interacting protein	Homo sapiens (human)
Partner and localizer of BRCA2		Homo sapiens (human)
E3 SUMO-protein ligase PIAS4	EC 2.3.2.27; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma; RING-type E3 ubiquitin transferase PIAS4	Homo sapiens (human)
RAD51-associated protein 1	HsRAD51AP1; RAD51-interacting protein	Homo sapiens (human)
RecQ-mediated genome instability protein 2	hRMI2; BLM-associated protein of 18 kDa; BLAP18	Homo sapiens (human)
BRCA1-A complex subunit RAP80	Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1	Homo sapiens (human)
Protein artemis	EC 3.1.-.-; DNA cross-link repair 1C protein; Protein A-SCID; SNM1 homolog C; hSNM1C; SNM1-like protein	Homo sapiens (human)
Structure-specific endonuclease subunit SLX1	EC 3.1.-.-; GIY-YIG domain-containing protein 1	Homo sapiens (human)
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	RAD9, RAD1, HUS1-interacting nuclear orphan protein	Homo sapiens (human)
TIMELESS-interacting protein		Homo sapiens (human)
RecQ-mediated genome instability protein 1	BLM-associated protein of 75 kDa; BLAP75; FAAP75	Homo sapiens (human)
Non-homologous end-joining factor 1	Protein cernunnos; XRCC4-like factor	Homo sapiens (human)
Claspin	hClaspin	Homo sapiens (human)
Serine/threonine-protein phosphatase 4 regulatory subunit 2		Homo sapiens (human)

Compounds (11)

Compound	Description
Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
adenosine diphosphate	Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
niacinamide	An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
o-acetyl-adp-ribose	An acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction.
nad	A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethionine	Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
Acetyl Coenzyme A	Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.