Page last updated: 2024-10-06

DDX58/IFIH1-mediated induction of interferon-alpha/beta

Proteins (46)

ProteinSynonymsTaxonomy
NucleoproteinN; Nucleocapsid protein; NC; Protein NSevere acute respiratory syndrome coronavirus 2
Mitochondrial antiviral-signaling proteinMAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter; VISAHomo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; EC 2.7.11.10; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB; 2.7.11.1Homo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16Homo sapiens (human)
Heat shock protein HSP 90-alphaEC 3.6.4.10; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38Homo sapiens (human)
Heat shock protein HSP 90-betaHSP 90; Heat shock 84 kDa; HSP 84; HSP84Homo sapiens (human)
Transcription factor p65Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3Homo sapiens (human)
Mitogen-activated protein kinase kinase kinase 1EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1Homo sapiens (human)
Caspase-8CASP-8; EC 3.4.22.61; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACHHomo sapiens (human)
Interferon regulatory factor 3IRF-3Homo sapiens (human)
Tumor necrosis factor alpha-induced protein 3TNF alpha-induced protein 3; EC 2.3.2.-; EC 3.4.19.12; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20Homo sapiens (human)
TRAF family member-associated NF-kappa-B activatorTRAF-interacting protein; I-TRAFHomo sapiens (human)
Interferon-induced helicase C domain-containing protein 1EC 3.6.4.13; Clinically amyopathic dermatomyositis autoantigen 140 kDa; CADM-140 autoantigen; Helicase with 2 CARD domains; Helicard; Interferon-induced with helicase C domain protein 1; Melanoma differentiation-associated protein 5; MDA-5; Murabutide dowHomo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase CYLDEC 3.4.19.12; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLDHomo sapiens (human)
Receptor-interacting serine/threonine-protein kinase 1EC 2.7.11.1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1Homo sapiens (human)
Serine/threonine-protein kinase TBK1EC 2.7.11.1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1Homo sapiens (human)
Interferon betaIFN-beta; Fibroblast interferonHomo sapiens (human)
E3 ubiquitin-protein ligase Itchy homologItch; EC 2.3.2.26; Atrophin-1-interacting protein 4; AIP4; HECT-type E3 ubiquitin transferase Itchy homolog; NFE2-associated polypeptide 1; NAPP1Homo sapiens (human)
NF-kappa-B essential modulatorNEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifierHomo sapiens (human)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EC 5.2.1.8; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1Homo sapiens (human)
CREB-binding proteinHistone lysine acetyltransferase CREBBP; 2.3.1.48; Protein-lysine acetyltransferase CREBBP; 2.3.1.-Homo sapiens (human)
Caspase-10CASP-10; EC 3.4.22.63; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4Homo sapiens (human)
Ubiquitin-like protein ATG12Autophagy-related protein 12; APG12-likeHomo sapiens (human)
Non-structural protein 1NS1; Non-structural protein 1CHuman respiratory syncytial virus A2
FAS-associated death domain proteinFAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; Protein FADDHomo sapiens (human)
Membrane proteinM; E1 glycoprotein; Matrix glycoprotein; Membrane glycoproteinSevere acute respiratory syndrome coronavirus 2
Advanced glycosylation end product-specific receptorReceptor for advanced glycosylation end productsHomo sapiens (human)
Poly(rC)-binding protein 2Alpha-CP2; Heterogeneous nuclear ribonucleoprotein E2; hnRNP E2Homo sapiens (human)
TNF receptor-associated factor 3EC 2.3.2.27; CAP-1; CD40 receptor-associated factor 1; CRAF1; CD40-binding protein; CD40BP; LMP1-associated protein 1; LAP1; RING-type E3 ubiquitin transferase TRAF3Homo sapiens (human)
Antiviral innate immune response receptor RIG-IDEAD box protein 58; Probable ATP-dependent RNA helicase DDX58; 3.6.4.13; RIG-I-like receptor 1; RLR-1; Retinoic acid-inducible gene 1 protein; RIG-1; Retinoic acid-inducible gene I protein; RIG-IHomo sapiens (human)
OTU domain-containing protein 5EC 3.4.19.12; Deubiquitinating enzyme A; DUBAHomo sapiens (human)
Protein NLRC5Caterpiller protein 16.1; CLR16.1; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4Homo sapiens (human)
Mitochondrial import receptor subunit TOM70Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70Homo sapiens (human)
Ubiquitin-like protein ISG15Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; IP17; Ubiquitin cross-reactive protein; hUCRPHomo sapiens (human)
E3 ubiquitin/ISG15 ligase TRIM25EC 6.3.2.n3; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc fingHomo sapiens (human)
Triokinase/FMN cyclaseBifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)Homo sapiens (human)
NLR family member X1Caterpiller protein 11.3; CLR11.3; Nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9Homo sapiens (human)
Tax1-binding protein 1TRAF6-binding proteinHomo sapiens (human)
Interferon regulatory factor 7IRF-7Homo sapiens (human)
Probable ATP-dependent RNA helicase DHX58EC 3.6.4.13; Probable ATP-dependent helicase LGP2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RLR-3; RIG-I-like receptor LGP2; RLRHomo sapiens (human)
E3 ubiquitin-protein ligase RNF125EC 2.3.2.27; RING finger protein 125; T-cell RING activation protein 1; TRAC-1Homo sapiens (human)
Suppressor of IKBKE 1Suppressor of IKK-epsilonHomo sapiens (human)
Autophagy protein 5APG5-like; Apoptosis-specific proteinHomo sapiens (human)
E3 ubiquitin-protein ligase RNF216EC 2.3.2.27; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 1; Zinc finger protein inhibiting NF-kappa-BHomo sapiens (human)
E3 ISG15--protein ligase HERC5EC 2.3.2.-; Cyclin-E-binding protein 1; HECT domain and RCC1-like domain-containing protein 5Homo sapiens (human)
ORF9b proteinORF9b; Accessory protein 9b; ORF-9b; Protein 9bSevere acute respiratory syndrome coronavirus 2

Compounds (3)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.