Page last updated: 2024-10-06

Cytosolic sensors of pathogen-associated DNA

Proteins (47)

ProteinSynonymsTaxonomy
Interferon-inducible protein AIM2Absent in melanoma 2Homo sapiens (human)
Three-prime repair exonuclease 1EC 3.1.11.2; 3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase IIIHomo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; EC 2.7.11.10; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB; 2.7.11.1Homo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16Homo sapiens (human)
Transcription factor p65Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3Homo sapiens (human)
Interferon regulatory factor 3IRF-3Homo sapiens (human)
Double-strand break repair protein MRE11EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog AHomo sapiens (human)
DNA-dependent protein kinase catalytic subunitDNA-PK catalytic subunit; DNA-PKcs; EC 2.7.11.1; DNPK1; p460Homo sapiens (human)
Receptor-interacting serine/threonine-protein kinase 1EC 2.7.11.1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1Homo sapiens (human)
Serine/threonine-protein kinase TBK1EC 2.7.11.1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1Homo sapiens (human)
Stimulator of interferon genes proteinhSTING; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173Homo sapiens (human)
Cyclic GMP-AMP synthasecGAMP synthase; cGAS; h-cGAS; EC 2.7.7.86; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1Homo sapiens (human)
Myeloid differentiation primary response protein MyD88Homo sapiens (human)
ATP-dependent DNA/RNA helicase DHX36EC 3.6.4.12; EC 3.6.4.13; DEAD/H box polypeptide 36; DEAH-box protein 36; G4-resolvase-1; G4R1; MLE-like protein 1; RNA helicase associated with AU-rich element proteinHomo sapiens (human)
Receptor-interacting serine/threonine-protein kinase 3EC 2.7.11.1; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3Homo sapiens (human)
NF-kappa-B essential modulatorNEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifierHomo sapiens (human)
Catenin beta-1Beta-cateninHomo sapiens (human)
Signal transducer and activator of transcription 6IL-4 StatHomo sapiens (human)
Leucine-rich repeat flightless-interacting protein 1LRR FLII-interacting protein 1; GC-binding factor 2; TAR RNA-interacting proteinHomo sapiens (human)
X-ray repair cross-complementing protein 6EC 3.6.4.-; EC 4.2.99.-; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNAHomo sapiens (human)
X-ray repair cross-complementing protein 5EC 3.6.4.-; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Lupus Ku autoantigen protein p86; NuHomo sapiens (human)
NACHT, LRR and PYD domains-containing protein 4Cancer/testis antigen 58; CT58; PAAD and NACHT-containing protein 2; PAN2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; PYPAF4; Ribonuclease inhibitor 2Homo sapiens (human)
TIR domain-containing adapter molecule 1TICAM-1; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; MyD88-3; TIR domain-containing adapter protein induciHomo sapiens (human)
Z-DNA-binding protein 1DNA-dependent activator of IFN-regulatory factors; DAI; Tumor stroma and activated macrophage protein DLM-1Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC4RNA polymerases I, II, and III subunit ABC4; ABC10-alpha; DNA-directed RNA polymerase II subunit K; RNA polymerase II 7.0 kDa subunit; RPB7.0; RPB10alphaHomo sapiens (human)
DNA-directed RNA polymerase III subunit RPC1RNA polymerase III subunit C1; EC 2.7.7.6; DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase III subunit A; RNA polymerase III 155 kDa subunit; RPC155; RNA polymerase III subunit C160Homo sapiens (human)
DNA-directed RNA polymerases I and III subunit RPAC1DNA-directed RNA polymerase I subunit C; RNA polymerases I and III subunit AC1; AC40; DNA-directed RNA polymerases I and III 40 kDa polypeptide; RPA40; RPA39; RPC40Homo sapiens (human)
DNA-directed RNA polymerase III subunit RPC9RNA polymerase III subunit C9; Calcitonin gene-related peptide-receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17Homo sapiens (human)
DNA-directed RNA polymerase III subunit RPC4RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RPC53 homologHomo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC1RNA polymerases I, II, and III subunit ABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; RPB5 homolog; XAP4Homo sapiens (human)
E3 ubiquitin-protein ligase TRIM21EC 2.3.2.27; 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro(SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC3RNA polymerases I, II, and III subunit ABC3; DNA-directed RNA polymerase II subunit H; DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide; RPB17; RPB8 homolog; hRPB8Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC2RNA polymerases I, II, and III subunit ABC2; DNA-directed RNA polymerase II subunit F; DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide; RPABC14.4; RPB14.4; RPB6 homolog; RPC15Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC5RNA polymerases I, II, and III subunit ABC5; DNA-directed RNA polymerase III subunit L; RNA polymerase II 7.6 kDa subunit; RPB7.6; RPB10 homologHomo sapiens (human)
ATP-dependent RNA helicase AEC 3.6.4.13; DEAH box protein 9; DExH-box helicase 9; Leukophysin; LKP; Nuclear DNA helicase II; NDH II; RNA helicase AHomo sapiens (human)
Gamma-interferon-inducible protein 16Ifi-16; Interferon-inducible myeloid differentiation transcriptional activatorHomo sapiens (human)
NLR family CARD domain-containing protein 3CARD15-like protein; Caterpiller protein 16.2; CLR16.2; NACHT, LRR and CARD domains-containing protein 3; Nucleotide-binding oligomerization domain protein 3Homo sapiens (human)
Interferon regulatory factor 7IRF-7Homo sapiens (human)
DNA-directed RNA polymerase III subunit RPC3RNA polymerase III subunit C3; DNA-directed RNA polymerase III subunit C; RNA polymerase III 62 kDa subunit; RPC62Homo sapiens (human)
DNA-directed RNA polymerase III subunit RPC6RNA polymerase III subunit C6; DNA-directed RNA polymerase III subunit F; RNA polymerase III 39 kDa subunit; RPC39Homo sapiens (human)
DNA-directed RNA polymerase III subunit RPC5RNA polymerase III subunit C5; DNA-directed RNA polymerase III 80 kDa polypeptideHomo sapiens (human)
DNA-directed RNA polymerase III subunit RPC2RNA polymerase III subunit C2; EC 2.7.7.6; C128; DNA-directed RNA polymerase III 127.6 kDa polypeptide; DNA-directed RNA polymerase III subunit BHomo sapiens (human)
Probable ATP-dependent RNA helicase DDX41EC 3.6.4.13; DEAD box protein 41; DEAD box protein abstrakt homologHomo sapiens (human)
E3 ubiquitin-protein ligase DTX4EC 2.3.2.27; Protein deltex-4; Deltex4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4Homo sapiens (human)
DNA-directed RNA polymerase III subunit RPC10RNA polymerase III subunit C10; DNA-directed RNA polymerase III subunit K; RNA polymerase III 12.5 kDa subunit; RPC12.5; RNA polymerase III subunit C11; HsC11p; RPC11; hRPC11Homo sapiens (human)
DNA-directed RNA polymerase III subunit RPC8RNA polymerase III subunit C8; DNA-directed RNA polymerase III subunit H; RNA polymerase III subunit 22.9 kDa subunit; RPC22.9Homo sapiens (human)
Protein POLR1D, isoform 2Homo sapiens (human)

Compounds (11)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
2'-deoxyguanosine 5'-phosphateRN given refers to parent cpd.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
bis(3',5')-cyclic diguanylic acid
cyclic guanosine monophosphate-adenosine monophosphate
Thymidine Monophosphate5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Deoxycytidine MonophosphateDeoxycytidine (dihydrogen phosphate). A deoxycytosine nucleotide containing one phosphate group esterified to the deoxyribose moiety in the 2'-,3'- or 5- positions.
2'-deoxyadenosine triphosphateRN given refers to unlabeled parent cpd