Page last updated: 2024-10-06

Citrate Cycle

Proteins (18)

ProteinSynonymsTaxonomy
2-oxoglutarate dehydrogenase, mitochondrialEC 1.2.4.2; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenaseCaenorhabditis elegans
Probable cytoplasmic aconitate hydrataseAconitase; EC 4.2.1.3; Citrate hydro-lyase; Gex-3-interacting protein 22Caenorhabditis elegans
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial EC 1.3.5.1; Flavoprotein subunit of complex II; FPCaenorhabditis elegans
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialEC 2.3.1.12; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2Caenorhabditis elegans
Probable malate dehydrogenase, mitochondrialEC 1.1.1.37Caenorhabditis elegans
Pyruvate carboxylase 1EC 6.4.1.1; Pyruvic carboxylase 1; PCB 1Caenorhabditis elegans
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialPDHE1-B; EC 1.2.4.1Caenorhabditis elegans
Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrialPDHE1-A; EC 1.2.4.1Caenorhabditis elegans
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialEC 6.2.1.4; EC 6.2.1.5; Succinyl-CoA synthetase subunit alpha; SCS-alphaCaenorhabditis elegans
Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrialEC 1.1.1.41; Isocitric dehydrogenase subunit beta; NAD(+)-specific ICDH subunit betaCaenorhabditis elegans
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialEC 1.1.1.41; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alphaCaenorhabditis elegans
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrialEC 6.2.1.4; GTP-specific succinyl-CoA synthetase subunit beta; G-SCS; GTPSCS; Succinyl-CoA synthetase beta-G chain; SCS-betaGCaenorhabditis elegans
Probable fumarate hydratase, mitochondrialFumarase; EC 4.2.1.2Caenorhabditis elegans
Probable citrate synthase, mitochondrialEC 2.3.3.16Caenorhabditis elegans
Probable ATP-citrate synthaseEC 2.3.3.8; ATP-citrate (pro-S-)-lyase; Citrate cleavage enzymeCaenorhabditis elegans
Isocitrate dehydrogenase [NADP] Caenorhabditis elegans
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Caenorhabditis elegans
Phosphoenolpyruvate carboxykinase Caenorhabditis elegans

Compounds (22)

CompoundDescription
pyruvic acidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Orthophosphate
succinic acidA water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
etodolacA non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
flunitrazepamA benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
hydrogen carbonate
hydroquinone
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Coenzyme A
phosphoenolpyruvateA monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in GLYCOLYSIS; GLUCONEOGENESIS; and other pathways.
isocitric acidRN given refers to unlabeled parent cpd
quinone
alpha-ketoglutaric acid
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
oxaloacetic acidA dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.
malic acid
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
aconitic acidA tricarboxylic acid with the formula (COOH)-CH2-C(COOH)=CH-COOH.